一些由 2-乙酰吡啶衍生的席夫碱及其金属配合物的抗菌评价。
Antibacterial evaluation of some Schiff bases derived from 2-acetylpyridine and their metal complexes.
机构信息
Chemistry Department, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia.
出版信息
Molecules. 2012 May 18;17(5):5952-71. doi: 10.3390/molecules17055952.
A series of Schiff bases derived from 2-acetylpyridne and their metal complexes were characterized by elemental analysis, NMR, FT-IR and UV-Vis spectral studies. The complexes were screened for anti-bacterial activity against Methicillin-resistant Staphylococcus aureus (MRSA), Acinetobacter baumanni (AC), Klebsiella pneumonie (KB) and Pseudomonas aeruginosa (PA) using the disc diffusion and micro broth dilution assays. Based on the overall results, the complexes showed the highest activities against MRSA while a weak antibacterial activity was observed against A. baumanii and P. aeruginosa.
一系列由 2-乙酰吡啶衍生而来的席夫碱及其金属配合物通过元素分析、NMR、FT-IR 和 UV-Vis 光谱研究进行了表征。采用圆盘扩散法和微量肉汤稀释法，对配合物进行了抗耐甲氧西林金黄色葡萄球菌（MRSA）、鲍曼不动杆菌（AC）、肺炎克雷伯菌（KB）和铜绿假单胞菌（PA）的抑菌活性筛选。根据综合结果，这些配合物对 MRSA 的活性最高，而对 A.baumanni 和 P. aeruginosa 的抑菌活性较弱。
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