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原发性肺内胸腺瘤伴重症肌无力。

Primary intrapulmonary thymoma associated with myasthenia gravis.

作者信息

Günaldi Meral, Oguz Kara I, Duman Berna Bozkurt, Gumurdulu Derya

机构信息

Department of Medical Oncology, Cukurova University Faculty of Medicine, Saricam, Adana 01330, Turkey.

出版信息

Gen Thorac Cardiovasc Surg. 2012 Sep;60(9):610-3. doi: 10.1007/s11748-012-0064-9. Epub 2012 May 19.

Abstract

Primary intrapulmonary thymomas are very rare. So far, research in the field has identified only 31 cases. In all databases, a total of two published articles describing primary intrapulmonary thymoma with myasthenia gravis were encountered between 1950 and 2010. We admitted a 58-year-old male patient with a mass in the right lower lobe of his lung. The tumor was excised, and histological findings were found to be consistent with Type AB thymoma. The patient was intubated due to respiratory distress during the postoperative period, and his acetylcholine receptor antibody was determined positive. He was diagnosed with myasthenia gravis. Pyridostigmine therapy and plasmapheresis were scheduled; yet, we could not begin therapy because of rapid deterioration of the patient's respiratory status due to myasthenia gravis and subsequently resulting in intubation-associated pneumonia. The patient's health rapidly worsened, and he died.

摘要

原发性肺内胸腺瘤非常罕见。到目前为止,该领域的研究仅发现了31例病例。在所有数据库中,1950年至2010年间共遇到两篇描述伴有重症肌无力的原发性肺内胸腺瘤的发表文章。我们收治了一名58岁男性患者,其右下肺有一个肿块。肿瘤被切除,组织学检查结果与AB型胸腺瘤一致。术后患者因呼吸窘迫而插管,其乙酰胆碱受体抗体检测呈阳性。他被诊断为重症肌无力。已安排使用吡啶斯的明治疗和血浆置换;然而,由于重症肌无力导致患者呼吸状况迅速恶化,随后引发插管相关性肺炎,我们无法开始治疗。患者健康状况迅速恶化,最终死亡。

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