Kazama Itsuro, Sasagawa Naoko, Nakajima Toshiyuki
Department of Physiology I, Tohoku University Graduate School of Medicine, Seiryo-cho, Aoba-ku, Sendai, Miyagi 980-8575, Japan.
Case Rep Med. 2012;2012:703281. doi: 10.1155/2012/703281. Epub 2012 Apr 24.
Two cases of women in their thirties with past histories of atopic dermatitis and allergic rhinitis developed a low grade fever, followed by a butterfly-shaped erythema, swelling of their fingers, and polyarthralgia. Despite such symptoms that overlap with those of systemic lupus erythematosus (SLE), the diagnostic criteria for SLE were not fulfilled. Due to positive results for human parvovirus B19 (HPV-B19) IgM antibodies in the serum, diagnoses of HPV-B19 infection were made in both cases. Although acetaminophen failed to improve their deteriorating symptoms, a nonsteroidal anti-inflammatory drug (NSAID), loxoprofen, completely removed the symptoms immediately after the administration. In those cases, since the patients were predisposed to atopic disorders, an increased immunological response based on the lymphocyte hypersensitivity was likely to be involved in the pathogenesis. The immunomodulatory property of NSAID was thought to repress such lymphocyte activity and thus provided a rapid and sustained remission of the disease.
两名三十多岁的女性，既往有特应性皮炎和过敏性鼻炎病史，先是出现低热，随后出现蝶形红斑、手指肿胀和多关节痛。尽管这些症状与系统性红斑狼疮（SLE）的症状重叠，但未满足SLE的诊断标准。由于血清中人类细小病毒B19（HPV-B19）IgM抗体检测结果呈阳性，两例均诊断为HPV-B19感染。虽然对乙酰氨基酚未能改善她们日益恶化的症状，但一种非甾体抗炎药（NSAID）洛索洛芬在给药后立即完全消除了症状。在这些病例中，由于患者易患特应性疾病，基于淋巴细胞超敏反应的免疫反应增强可能参与了发病机制。NSAID的免疫调节特性被认为可抑制此类淋巴细胞活性，从而使疾病迅速并持续缓解。
