Feizy Vida, Ghobadi Arefeh
Department of Dermatology, Tehran University of Medical Sciences.
Dermatol Online J. 2006 Mar 30;12(3):3.
Atopic dermatitis (AD) has a Th2 (T-helper 2) immune-reactivity pattern. However, the majority of systemic autoimmune diseases, such as rheumatoid arthritis, multiple sclerosis, and insulin dependent diabetes mellitus show a Th1 (T-helper 1) reactivity pattern. From this, one may hypothesize that AD and the Th1 autoimmune diseases could be inversely associated and AD may be more common in the minority of autoimmune diseases with a Th2 overactivity pattern such as systemic lupus erythematosus. A cross sectional study was designed. Our patients were enrolled from a general university hospital (all systemic autoimmune patients in every medical ward based on definite diagnoses in their medical records). Information on atopic dermatitis was obtained by questionnaires and physical examination by a dermatologist. A total of 63 patients were studied; 17.5 percent of cases had atopic dermatitis in the past or present. There were 31 patients 49.2 %) who carried a diagnosis known to be associated with Th1 reaction, and 21 patients (33.3 %) who had a disease associated with Th2-type reactivity. In 11 patients (17.5 %) the T-cell reaction type was not definitively classified. The relative frequency of AD was 9.7 percent (3 of 31 cases) in Th1-related autoimmune diseases, 28.6 percent (6 of 21 cases) in Th2-related autoimmune diseases and 18.2 percent (2 of 11 cases) in the unclassified category, a difference not statistically significant. Although the power of this study is not high enough to show a statistical significance, AD seems to be uncommon in patients with autoimmune diseases associated with Th1 overactivity.
特应性皮炎（AD）具有Th2（辅助性T细胞2）免疫反应模式。然而，大多数系统性自身免疫性疾病，如类风湿性关节炎、多发性硬化症和胰岛素依赖型糖尿病，表现出Th1（辅助性T细胞1）反应模式。据此，有人可能会推测，AD与Th1自身免疫性疾病可能呈负相关，且AD在少数具有Th2过度活跃模式的自身免疫性疾病（如系统性红斑狼疮）中可能更为常见。设计了一项横断面研究。我们的患者来自一家综合大学医院（根据病历中的明确诊断，每个内科病房的所有系统性自身免疫性疾病患者）。通过问卷调查和皮肤科医生的体格检查获取有关特应性皮炎的信息。共研究了63例患者；17.5%的病例过去或现在患有特应性皮炎。有31例患者（49.2%）被诊断为与Th1反应相关，21例患者（33.3%）患有与Th2型反应相关的疾病。11例患者（17.5%）的T细胞反应类型未明确分类。AD在Th1相关自身免疫性疾病中的相对发生率为9.7%（31例中的3例），在Th2相关自身免疫性疾病中为28.6%（21例中的6例），在未分类组中为18.2%（11例中的2例），差异无统计学意义。尽管本研究的效力不足以显示统计学意义，但AD在与Th1过度活跃相关的自身免疫性疾病患者中似乎并不常见。
