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住院老年患者贫血患病率及转铁蛋白受体(sTfR)在缺铁性贫血诊断中的评估:智利贫血临床研究

Prevalence of Anaemia and Evaluation of Transferrin Receptor (sTfR) in the Diagnosis of Iron Deficiency in the Hospitalized Elderly Patients: Anaemia Clinical Studies in Chile.

作者信息

López-Sierra Mauricio, Calderón Susana, Gómez Jorge, Pilleux Lilian

机构信息

Hematology Unit, Institute of Medicine, Faculty of Medicine, Universidad Austral de Chile, Bueras 1003 CP 5090000 Valdivia, Chile.

出版信息

Anemia. 2012;2012:646201. doi: 10.1155/2012/646201. Epub 2012 May 3.

Abstract

Iron constitutes the most prevalent nutritional deficiency worldwide. In Chile, anaemia epidemiological data is scarce, evaluating mainly children and women. Our objective was to determine prevalence of anaemia in an inpatient elderly population (≥60 years) and assess the usefulness of sTfR levels analyzed by other authors as a good predictor in the differential diagnosis of iron deficiency anaemia and anaemia of chronic disease. Method. We studied medical patients admitted at Hospital of Valdivia (HV), Chile, in a 2month period. World Health Organization criteria were used for anaemia. Results. 391 patients were hospitalized, average age 62.5 years, 247 elderly and 99 of which had anaemia. Anaemia was normocytic in 88.8%, and we observed: low serum iron in 46.3%, low ferritin 10.1%, high TIBC 2%, low % transferrin saturation (Tsat) 40%, and high sTfR 25%. Conclusions. As a first figure known in Chile, the prevalence of anaemia in the elderly inpatient was 40.1%. Our findings encourage us to promote the implementation of sTfR determination in the clinical setting to analyze the state of erythropoiesis in patients with chronic diseases wich commonly occurs in elderly.

摘要

铁缺乏是全球最普遍的营养缺乏症。在智利,贫血的流行病学数据匮乏,主要针对儿童和女性进行评估。我们的目标是确定老年住院患者(≥60岁)贫血的患病率,并评估其他作者分析的可溶性转铁蛋白受体(sTfR)水平在缺铁性贫血和慢性病贫血鉴别诊断中作为良好预测指标的有效性。方法。我们对智利瓦尔迪维亚医院(HV)在2个月期间收治的内科患者进行了研究。采用世界卫生组织的贫血标准。结果。共收治391例患者,平均年龄62.5岁,其中247例为老年人,99例患有贫血。88.8%的贫血为正细胞性贫血,我们观察到:血清铁降低46.3%,铁蛋白降低10.1%,总铁结合力升高2%,转铁蛋白饱和度(Tsat)降低40%,sTfR升高25%。结论。作为智利已知的首个数据,老年住院患者贫血的患病率为40.1%。我们的研究结果促使我们推动在临床环境中开展sTfR测定,以分析老年患者中常见的慢性病患者的红细胞生成状态。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ccc4/3352183/da600c0251b4/ANE2012-646201.001.jpg

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