Department of Aging Medicine and Aging Research, University Hospital Zurich and University of Zurich, Raemistrasse 101, 8091, Zurich, Switzerland.
Centre on Aging and Mobility, University Hospital Zurich and City Hospital Zurich, Waid, Zurich, Switzerland.
Aging Clin Exp Res. 2022 Mar;34(3):515-525. doi: 10.1007/s40520-021-01955-3. Epub 2021 Sep 17.
The longitudinal association between iron deficiency and inflammatory biomarkers levels has not been fully explored among relatively healthy older adults.
To assess whether iron deficiency at baseline and at any yearly follow-up time point, with or without anemia, was associated with changes from baseline in high-sensitivity C-reactive protein (hs-CRP) and interleukin-6 (IL-6) levels over 3 years.
This is a post-hoc observational analysis of DO-HEALTH, a double-blind, randomized controlled trial including 2157 European community-dwelling adults age 70+. The outcomes were changes from baseline in hs-CRP and IL-6 levels, measured at 12, 24, and 36 months of follow-up. Iron deficiency was defined by soluble transferrin receptor levels > 28.1 nmol/L and baseline anemia by hemoglobin levels < 130 g/L for men and < 120 g/L for women.
In total, 2141 participants were included in the analyses (mean age: 74.9 years, 61.5% of women, 26.8% with iron deficiency). Baseline iron deficiency was associated with greater increase in IL-6 levels (mean difference in change: 0.52 ng/L, 95%CI 0.03-1.00, P = .04) over 3 years. Iron deficiency at any yearly time point was associated with higher increases in hs-CRP (mean difference in change: 1.62 mg/L, 95%CI 0.98-2.26, P < .001) and IL-6 levels (mean difference in change: 1.33 ng/L, 95%CI 0.87-1.79, P < .001) over 3 years. No significant interaction between iron deficiency and anemia was found, suggesting that the results are independent of the anemic status.
These findings suggest that iron deficiency may play a role in low-grade chronic inflammation among relatively healthy older adults.
铁缺乏症与炎症生物标志物水平之间的纵向关联在相对健康的老年人中尚未得到充分探讨。
评估基线时以及任何一年随访时间点是否存在缺铁症（无论是否伴有贫血）与基线时的高敏 C 反应蛋白（hs-CRP）和白细胞介素 6（IL-6）水平在 3 年内的变化是否相关。
这是 DO-HEALTH 的事后观察性分析，这是一项双盲、随机对照试验，纳入了 2157 名年龄在 70 岁以上的欧洲社区居住的成年人。结局是在 12、24 和 36 个月的随访中，hs-CRP 和 IL-6 水平从基线的变化。铁缺乏症的定义是可溶性转铁蛋白受体水平＞28.1 nmol/L，男性基线时贫血定义为血红蛋白水平＜130 g/L，女性为血红蛋白水平＜120 g/L。
共纳入 2141 名参与者进行分析（平均年龄：74.9 岁，61.5%为女性，26.8%患有缺铁症）。基线时缺铁症与 IL-6 水平升高（变化的平均差异：0.52ng/L，95%CI 0.03-1.00，P=0.04）有关。在任何一年的时间点，缺铁症与 hs-CRP（变化的平均差异：1.62mg/L，95%CI 0.98-2.26，P＜0.001）和 IL-6 水平（变化的平均差异：1.33ng/L，95%CI 0.87-1.79，P＜0.001）升高有关。未发现缺铁症和贫血之间存在显著的交互作用，这表明结果独立于贫血状态。
这些发现表明，铁缺乏可能在相对健康的老年人中发挥作用，引起低度慢性炎症。
