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[河南人群代谢酶与DNA修复酶基因多态性与肺癌易感性的关系]

[Association between genetic polymorphism of metabolizing enzymes and DNA repairing enzymes and the susceptibility of lung cancer in Henan population].

作者信息

Wang Na, Wu Yongjun, Zhou Xiaolei, Wu Yiming

机构信息

School of Public Health, Zhengzhou University, Zhengzhou 450001, China.

出版信息

Wei Sheng Yan Jiu. 2012 Mar;41(2):251-6.

Abstract

OBJECTIVE

To investigate the association between genetic polymorphism of metabolizing enzymes and DNA repairing enzymes and the susceptibility of pulmonary cancer in Henan population.

METHODS

A case-control study of 209 lung cancer patients and 256 healthy control subjects was conducted in Henan population to investigate the role of CYP1A1-Msp1, CYP1A1-exon7, GSTM1, GSTT1, mEH-exon3, mEH-exon4 and XRCC1 in lung cancer. Genotyping was performed by using PCR based restriction fragment length polymorhphism techniques.

RESULTS

The frequency of GSTM1-null, CYP1A1-exon7 mt/mt, mEH-exon3 mt/mt, XRCC1-194 Trp/Trp, XRCC1-280 His/His genotype in the lung cancer case group was significantly higher than that in control group (P < 0.05). The risk of lung cancer was higher in individuals carrying genotypes of GSTM1 (ORadj = 1.76, 95% CI 1.21-2.56, P = 0.005), CYP1A1-exon7 Ile/val + val/val (ORadj = 1.65, 95% CI 1.16-2.39, P = 0.009), mEH-exon3 wt/mt + mt/mt (ORadj = 1.77, 95% CI 1.18-2.64, P = 0.007), XRCC1-194 Arg/Trp + Trp/Trp (ORadj = 1.55, 95% CI 1.07-2.27, P = 0.016) and XRCC1-280 His/His (ORadj = 2.21, 95% CI 1.05-4.52, P = 0.026) than those carrying genotypes of GSTM1 null, CYP1A1-exon7 Ile/Ile, mEH-exon3 wt/wt, XRCC1-194 Arg/Arg and XRCC1-280 Arg/ Arg + Arg/His; There was no significant difference for CYP1A1-Msp1, GSTT1, mEH-exon4, XRCC1-399 genotype between the two groups (P > 0.05).

CONCLUSION

The genetic polymorphisms of CYP1A1-exon7, GSTM1, mEH-exon3, XRCC1-194 and XRCC1-280 might contribute to the risk of developing lung cancer in Henan population.

摘要

目的

探讨代谢酶和DNA修复酶基因多态性与河南人群肺癌易感性之间的关联。

方法

对河南人群中209例肺癌患者和256例健康对照者进行病例对照研究,以探讨CYP1A1-Msp1、CYP1A1外显子7、GSTM1、GSTT1、mEH外显子3、mEH外显子4和XRCC1在肺癌中的作用。采用基于聚合酶链反应的限制性片段长度多态性技术进行基因分型。

结果

肺癌病例组中GSTM1缺失、CYP1A1外显子7 mt/mt、mEH外显子3 mt/mt、XRCC1-194 Trp/Trp、XRCC1-280 His/His基因型的频率显著高于对照组(P<0.05)。携带GSTM1(ORadj = 1.76,95%CI 1.21-2.56,P = 0.005)、CYP1A1外显子7 Ile/val + val/val(ORadj = 1.65,95%CI 1.16-2.39,P = 0.009)、mEH外显子3 wt/mt + mt/mt(ORadj = 1.77,95%CI 1.18-2.64,P = 0.007)、XRCC1-194 Arg/Trp + Trp/Trp(ORadj = 1.55,95%CI 1.07-2.27,P = 0.016)和XRCC1-280 His/His(ORadj = 2.21,95%CI 1.05-4.52,P = 0.026)基因型的个体患肺癌的风险高于携带GSTM1缺失、CYP1A1外显子7 Ile/Ile、mEH外显子3 wt/wt、XRCC1-194 Arg/Arg和XRCC1-280 Arg/Arg + Arg/His基因型的个体;两组之间CYP1A1-Msp1、GSTT1、mEH外显子4、XRCC1-399基因型无显著差异(P>0.05)。

结论

CYP1A1外显子7、GSTM1、mEH外显子3、XRCC1-194和XRCC1-280的基因多态性可能与河南人群患肺癌的风险有关。

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