Rattanalappaiboon Duangporn, Werawatakul Yuthapong, Tharnprisan Piangjit, Prasit Molruedee
Department of Obstetrics and Gynecology, Faculty of Medicine, Srinagarind Hospital, Khon Kaen University, Khon Kaen, Thailand.
J Med Assoc Thai. 2012 Apr;95(4):477-81.
To evaluate the effectiveness and determine the minimal dosage of intraperitoneal lidocaine for pain relief during postpartum tubal resection in Srinagarind Hospital.
Sixty postpartum women, undergoing postpartum tubal resection performed by residents at the Department of obstetrics and gynecologic, were included in this randomized, double-blinded, placebo controlled study. They were randomly assigned to one of three groups. They all received 20 ml solution intraperitoneally. Group one received it as isotonic normal saline; group 2 received it with 100 mg of lidocaine; and group 3 received it with 200 mg of lidocaine. The intra-operative and post-operative pain was measured by using a numerical rating score (NRS, from 0-10).
The mean of intra-operative NRS in the lidocaine groups (100 and 200 mg) were significantly lower than the isotonic normal saline group (3.40, 3.50 vs. 6.55, p-value 0.019 and 0.024). No significant difference was found in the intra-operative NRS between 100 and 200 mg lidocaine (NRS 3.40 vs. 3.50, respectively, mean difference 95% CI -2.41 to 2.21). There was no significant difference in the immediate post-operative pain among these three groups (p-value 0.613).
Intraperitoneal lidocaine instillation provides effective intra-operative pain relief in postpartum tubal resection under local anesthesia. 100 mg of lidocaine is effective in pain relief This technique was not effective for relief of immediate post-operative pain.
评估在诗里拉吉医院产后输卵管切除术中腹腔内注射利多卡因缓解疼痛的有效性，并确定其最小剂量。
本随机、双盲、安慰剂对照研究纳入了60名在妇产科由住院医师进行产后输卵管切除术的产后妇女。她们被随机分为三组。三组均经腹腔注射20毫升溶液。第一组注射等渗生理盐水；第二组注射含100毫克利多卡因的溶液；第三组注射含200毫克利多卡因的溶液。术中及术后疼痛采用数字评分量表（NRS，0至10分）进行测量。
利多卡因组（100毫克和200毫克）术中NRS的平均值显著低于等渗生理盐水组（3.40、3.50对6.55，p值分别为0.019和0.024）。100毫克和200毫克利多卡因组的术中NRS无显著差异（NRS分别为3.40和3.50，平均差异95%CI为-2.41至2.21）。三组术后即刻疼痛无显著差异（p值为0.613）。
腹腔内注射利多卡因可在局部麻醉下的产后输卵管切除术中有效缓解术中疼痛。100毫克利多卡因即可有效缓解疼痛。该技术对缓解术后即刻疼痛无效。
