Department of Experimental Biomedicine and Clinical Neuroscience, University of Palermo, Palermo, Italy.
Int J Oncol. 2012 Aug;41(2):407-13. doi: 10.3892/ijo.2012.1476. Epub 2012 May 14.
In recent years, cannabinoids (the active components of Cannabis sativa) and their derivatives have received considerable interest due to findings that they can affect the viability and invasiveness of a variety of different cancer cells. Moreover, in addition to their inhibitory effects on tumor growth and migration, angiogenesis and metastasis, the ability of these compounds to induce different pathways of cell death has been highlighted. Here, we review the most recent results generating interest in the field of death mechanisms induced by cannabinoids in cancer cells. In particular, we analyze the pathways triggered by cannabinoids to induce apoptosis or autophagy and investigate the interplay between the two processes. Overall, the results reported here suggest that the exploration of molecular mechanisms induced by cannabinoids in cancer cells can contribute to the development of safe and effective treatments in cancer therapy.
近年来，由于发现大麻素（大麻的活性成分）及其衍生物可以影响多种不同癌细胞的活力和侵袭性，因此它们受到了相当大的关注。此外，除了抑制肿瘤生长和迁移、血管生成和转移外，这些化合物诱导细胞死亡不同途径的能力也得到了强调。在这里，我们综述了近年来在大麻素诱导癌细胞死亡机制领域引起关注的最新研究结果。特别是，我们分析了大麻素诱导细胞凋亡或自噬的途径，并研究了这两个过程之间的相互作用。总的来说，这里报道的结果表明，对大麻素在癌细胞中诱导的分子机制的探索可以为癌症治疗中安全有效的治疗方法的开发做出贡献。
