Ukai Masayasu, Kurihara Jade, Antonakakis Markos, Banks Krista, Dow Steve, Gustafson Daniel L, Boss Mary-Keara, Prebble Amber, McGrath Stephanie
Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA.
Brain Research Center, Colorado State University, Fort Collins, CO 80523, USA.
Vet Sci. 2025 Aug 5;12(8):735. doi: 10.3390/vetsci12080735.
Glioma is a type of neoplasia that spontaneously arises from the glial cells of the brain in humans and dogs, and its prognosis is grave. Current treatment options for glioma include surgery, radiation therapy, chemotherapy, or symptomatic treatment. Evidence has shown that cannabidiol (CBD) may have anticancer, anti-angiogenic, and anti-inflammatory properties in both in vitro and in vivo studies. In this in vivo murine experiment, the canine glioma cell line J3TBG was injected into the frontoparietal cortex of immunodeficient mice using xenogeneic tissue transplantation. A total of 20 mice were randomly assigned to one of four treatment groups-Control group (C), CBD group (CBD), Radiation Therapy group (RT), and CBD plus Radiation Therapy group (CBD + RT). After transplantation of J3TBG, a single fraction of 5.5 Gy RT was administered to the RT and CBD + RT groups, and CBD was administered daily to the CBD and CBD + RT groups. Necropsies were performed to collect blood and brain tissue. Although there was not a statistically significant difference, the survival time among mice were longer in the CBD + RT group than the RT group. These results indicate that CBD may be used as an adjunctive therapy to enhance RT treatment. Larger cohort studies are required to substantiate the hypothesis.
胶质瘤是一种在人类和犬类中由脑胶质细胞自发产生的肿瘤，其预后严重。目前胶质瘤的治疗选择包括手术、放射治疗、化疗或对症治疗。有证据表明，在体外和体内研究中，大麻二酚（CBD）可能具有抗癌、抗血管生成和抗炎特性。在这项体内小鼠实验中，使用异种组织移植将犬胶质瘤细胞系J3TBG注入免疫缺陷小鼠的额顶叶皮质。总共20只小鼠被随机分配到四个治疗组之一——对照组（C）、CBD组（CBD）、放射治疗组（RT）和CBD加放射治疗组（CBD + RT）。在移植J3TBG后，对RT组和CBD + RT组给予单次5.5 Gy的放射治疗，对CBD组和CBD + RT组每日给予CBD。进行尸检以收集血液和脑组织。虽然没有统计学上的显著差异，但CBD + RT组小鼠的生存时间比RT组长。这些结果表明，CBD可作为辅助治疗来增强放射治疗效果。需要更大规模的队列研究来证实这一假设。
