Abi1，一种关键分子，协调肌动蛋白细胞骨架重组与 PI-3 激酶和生长信号。
Abi1, a critical molecule coordinating actin cytoskeleton reorganization with PI-3 kinase and growth signaling.
机构信息
New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA.
出版信息
FEBS Lett. 2012 Aug 14;586(17):2790-4. doi: 10.1016/j.febslet.2012.05.015. Epub 2012 May 19.
Abstract
Coordination of actin cytoskeletal reorganization with growth and proliferation signals is a key cellular process that is not fully understood. PI-3 kinase is one of the central nodes for distributing growth and proliferation signals downstream from growth factor receptors to the nucleus. Although PI-3 kinase function has been associated with actin cytoskeleton remodeling, satisfactory explanations of the mechanisms mediating this regulation have been elusive. Here we propose that interaction of the Abi1 protein with the p85 regulatory subunit of PI-3 kinase represents the link between growth receptor signaling and actin cytoskeleton remodeling. This function of Abi1, which involves WAVE complex, was initially observed in macropinocytosis, and may explain the coincident dysregulation of PI-3 kinase and actin cytoskeleton in cancer.
摘要
细胞骨架的重排与生长和增殖信号的协调是一个尚未完全理解的关键细胞过程。PI-3 激酶是将生长因子受体下游的生长和增殖信号分配到细胞核的中心节点之一。尽管 PI-3 激酶的功能与肌动蛋白细胞骨架的重塑有关，但介导这种调节的机制仍难以令人满意。在这里，我们提出 Abi1 蛋白与 PI-3 激酶的 p85 调节亚基的相互作用代表了生长受体信号与肌动蛋白细胞骨架重塑之间的联系。Abi1 的这个功能涉及 WAVE 复合物，最初在巨胞饮作用中观察到，可能解释了癌症中 PI-3 激酶和肌动蛋白细胞骨架的同时失调。
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Nat Rev Mol Cell Biol. 2012 Feb 23;13(3):195-203. doi: 10.1038/nrm3290.
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J Biol Chem. 2011 Nov 4;286(44):38614-38626. doi: 10.1074/jbc.M111.281139. Epub 2011 Sep 7.
3
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Proc Natl Acad Sci U S A. 2011 Aug 30;108(35):14449-54. doi: 10.1073/pnas.1107666108. Epub 2011 Aug 15.
4
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Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):7022-7. doi: 10.1073/pnas.1016811108. Epub 2011 Apr 11.
5
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J Cell Biol. 2011 Apr 4;193(1):61-70. doi: 10.1083/jcb.201007003.
6
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7
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9
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10
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