Honda M, Omori Y, Minei S, Oshiyama T, Shimizu M, Sanaka M, Kohama T, Nakabayashi M, Hirata Y
Diabetes Centre, Tokyo Women's Medical College, Japan.
Diabetes Res Clin Pract. 1990 Oct;10(2):147-52. doi: 10.1016/0168-8227(90)90037-t.
In an attempt to clarify the mechanism of lipid metabolism during pregnancy, alpha 1-acid glycoprotein (alpha 1-AG) was analyzed in normal and diabetic pregnant women. Seventy-two determinations of serum alpha 1-AG levels were performed in 18 diabetic pregnant women and 82 determinations in 82 normal pregnant women in all three trimesters and within 14 days postpartum. Serum alpha 1-AG levels in both normal and diabetic pregnant women decreased throughout pregnancy and rapidly increased postpartum. In all gestational stages, the serum alpha 1-AG levels were lower in diabetic women than in normal women, but the differences were not significant. No significant correlation was obtained between serum alpha 1-AG and hemoglobin A1 (HbA1) in diabetic patients. On the contrary, the serum triglyceride levels increased during pregnancy and decreased postpartum in both groups of subjects. These findings suggest that serum alpha 1-AG plays an important role in the activation of lipoprotein lipase during pregnancy.
为了阐明孕期脂质代谢的机制，对正常孕妇和糖尿病孕妇的α1-酸性糖蛋白（α1-AG）进行了分析。在18名糖尿病孕妇中进行了72次血清α1-AG水平测定，在82名正常孕妇中进行了82次测定，涵盖整个孕期的三个阶段以及产后14天内。正常孕妇和糖尿病孕妇的血清α1-AG水平在整个孕期均下降，产后迅速升高。在所有妊娠阶段，糖尿病孕妇的血清α1-AG水平均低于正常孕妇，但差异不显著。糖尿病患者血清α1-AG与糖化血红蛋白A1（HbA1）之间未获得显著相关性。相反，两组受试者的血清甘油三酯水平在孕期升高，产后下降。这些发现表明，血清α1-AG在孕期脂蛋白脂肪酶的激活中起重要作用。
