Briese V, Müller H, Stiete H
Klinik für Gynäkologie und Geburtshilfe, Universität Rostock.
Zentralbl Gynakol. 1995;117(1):17-22.
Follow up studies regarding lipid metabolism in diabetic pregnancy are important in maternal and fetal morbidity.
With this background it is particularly opportune to consider the difference of cholesterol, triglycerides and HDL-cholesterol of diabetics and nondiabetics in pregnancy. In addition the correlation of lipids to the glycosylated hemoglobin (HbA1), White groups and other clinical parameters is of interest. Attention is given to the comparison of insulin dependent diabetics (IDDM) and gestational diabetes (GDM) in the 3rd trimester.
A diabetic group of 84 patients (IDDM, GDM) was used for the prospective study over a two years period. The lipid metabolism was estimated preconceptionally, during pregnancy and on 7th day after delivery. 36 pregnant healthy women served as controls. The information obtained from each patient was entered into an SPSS data base. Statistical analysis were done by Mann-Whitney U and Kruskall-Wallis test and by means of Pearson's correlation coefficient to correlate with age, parity, body mass index, creatinin, albumiuria, HbA1, blood pressure.
There were no any correlations between lipid parameters cholesterol, triglycerides, HDL-C, beta-lipoprotein and HbA1 as well as White groups (Pearson's coefficient). The triglyceride levels were significant lower in diabetic pregnants compared with healthy controls (p = 0.0095; Wilcoxon Test); diabetes: mean = 1,831 mmol/l; min 0.35; max 5.99 and control group mean = 2,133 mmol/l; min 0.36; max 4.70. Cholesterol levels were higher in the 3rd trimester of GDM patients than values of IDDM's (p = 0.0017; Wilcoxon Test). The longitudinal study during diabetic pregnancy resulted in significantly progressive increase in cholesterol and triglyceride levels (p = 0.0035 bzw. p = 0.0099; Kruskal-Wallis Test).
Significant lower triglyceride levels had been found in diabetic pregnants than in healthy controls. There was no any correlation between lipid parameters cholesterol, triglycerides, HDL-cholesterol, beta-lipoprotein on the one side and HbA1 and White groups on the other side. Increased cholesterol levels were noted in the 3rd trimester of pregnancy in the gestational diabetes in comparison of insulin dependent pregnant diabetics.
关于糖尿病妊娠脂质代谢的随访研究对母婴发病率很重要。
在此背景下，特别适合考虑糖尿病孕妇和非糖尿病孕妇在胆固醇、甘油三酯和高密度脂蛋白胆固醇方面的差异。此外，脂质与糖化血红蛋白（HbA1）、怀特分类以及其他临床参数的相关性也备受关注。重点关注妊娠晚期胰岛素依赖型糖尿病（IDDM）和妊娠期糖尿病（GDM）的比较。
84例糖尿病患者（IDDM、GDM）组成的糖尿病组用于为期两年的前瞻性研究。在孕前、孕期及产后第7天评估脂质代谢。36名健康孕妇作为对照。将从每位患者获得的信息录入SPSS数据库。采用曼-惠特尼U检验和克鲁斯卡尔-沃利斯检验以及皮尔逊相关系数进行统计分析，以与年龄、产次、体重指数、肌酐、蛋白尿、HbA1、血压进行相关性分析。
脂质参数胆固醇、甘油三酯、高密度脂蛋白胆固醇、β-脂蛋白与HbA1以及怀特分类之间均无相关性（皮尔逊系数）。糖尿病孕妇的甘油三酯水平显著低于健康对照组（p = 0.0095；威尔科克森检验）；糖尿病组：均值 = 1.831 mmol/l；最小值0.35；最大值5.99，对照组均值 = 2.133 mmol/l；最小值0.36；最大值4.70。GDM患者妊娠晚期的胆固醇水平高于IDDM患者（p = 0.0017；威尔科克森检验）。糖尿病妊娠期间的纵向研究显示胆固醇和甘油三酯水平显著逐渐升高（p = 0.0035和p = 0.0099；克鲁斯卡尔-沃利斯检验）。
糖尿病孕妇的甘油三酯水平显著低于健康对照组。一方面脂质参数胆固醇、甘油三酯、高密度脂蛋白胆固醇、β-脂蛋白与另一方面的HbA1和怀特分类之间均无相关性。与胰岛素依赖型妊娠糖尿病患者相比，妊娠期糖尿病患者妊娠晚期的胆固醇水平升高。
