Pavone Venere Leda, Scarnato C, Marinilli Pasqualina, Costellati L, Tiranno Anna, Alberghini V, Pandolfi P
Azienda USL di Bologna, Dipartimento di Sanità Pubblica, Area Prevenzione e Sicurezza Ambienti di Lavoro di Bologna.
Med Lav. 2012 Mar-Apr;103(2):112-22.
A private company in Bologna worked for the Italian State Railways (FS) from 1919 to 1998; since the early '60s it used asbestos for new carriage insulation and renovation of carriages already circulating which were entirely spray-coated with asbestos.
The study aimed to investigate all causes mortality, in particular mortality from asbestos-related neoplasms in blue-collar workers.
The cohort consisted of 1,849 people, active in 1960 or hired in 1960-86: 1,704 (92.2%) blue-collar workers and 145 (7.8%) white-collar workers. The end date of the follow up was established as 31/12/2008. Regional reference mortality rates were used.
Mortality from all causes (SMR = 1.16; 95% CI 1.08-1.25) and from malignant neoplasms (SMR = 1.20; 95% CI 1.06-1.35) significantly exceeded expected rates. In particular, a statistically significant increase was observed for pleural malignant cancer (SMR = 24.43; 95% CI 17.37-34.37), lung cancer (SMR = 1.24; 95% CI 1.00-1.53), peritoneal cancer (SMR = 6.35; 95% CI 2.64-15.25) and bladder cancer (SMR = 1.71; 95% CI 1.03-2.84). The excess lung cancer SMR was highly significant after 20 years of exposure and with a latency longer than 40 years. An association between pleural malignant cancer and duration of exposure and latency (trend test p value < 0,0001) was observed
This study on a cohort of asbestos-exposed workers showed an increase in lung cancer SMRs by risk that was statistically significant in workers exposed for at least 20 years and after 40 years of latency. The neoplasm of pleura was strongly associated with both duration of exposure and latency.
博洛尼亚的一家私人公司在1919年至1998年期间为意大利国家铁路公司（FS）工作；自20世纪60年代初以来，该公司将石棉用于新车厢隔热以及对已投入运营的车厢进行翻新，这些车厢全部用石棉进行了喷涂。
该研究旨在调查所有原因导致的死亡率，特别是蓝领工人中与石棉相关肿瘤的死亡率。
该队列由1849人组成，他们在1960年在职或于1960 - 1986年期间受雇：1704人（92.2%）为蓝领工人，145人（7.8%）为白领工人。随访截止日期设定为2008年12月31日。使用了地区参考死亡率。
所有原因导致的死亡率（标准化死亡比SMR = 1.16；95%置信区间1.08 - 1.25）以及恶性肿瘤导致的死亡率（SMR = 1.20；95%置信区间1.06 - 1.35）显著超过预期死亡率。特别是，观察到胸膜恶性肿瘤（SMR = 24.43；95%置信区间17.37 - 34.37）、肺癌（SMR = 1.24；95%置信区间1.00 - 1.53）、腹膜癌（SMR = 6.35；95%置信区间2.64 - 15.25）和膀胱癌（SMR = 1.71；95%置信区间1.03 - 2.84）的死亡率有统计学显著增加。在接触20年后且潜伏期超过40年时，肺癌的超额SMR非常显著。观察到胸膜恶性肿瘤与接触时长和潜伏期之间存在关联（趋势检验p值 < 0.0001）。
这项对接触石棉工人队列的研究表明，在至少接触20年且潜伏期超过40年的工人中，肺癌的SMR因风险增加而具有统计学显著性。胸膜肿瘤与接触时长和潜伏期都密切相关。
