Zanetti R, Franceschi S, Rosso S, Bidoli E, Colonna S
Piemonte Cancer Registry, Turin, Italy.
Int J Epidemiol. 1990 Sep;19(3):522-6. doi: 10.1093/ije/19.3.522.
The role of hormonal and reproductive factors as risks for cutaneous malignant melanoma (CMM) was explored by means of a population-based case-control study conducted in Turin, north-western Italy, on 186 female CMM cases and 205 controls. Past use of oral contraceptives (OC) did not seem to exert any effect on CMM risk odds ratio (OR) = 1.12, 95% confidence interval (CI): 0.56-2.24). No association was found even for the longest duration of use, for superficial spreading melanoma cases and for CMM of lower limbs only. While age at first birth did not affect CMM risk, women who had had three or more children seemed to be significantly protected as compared to nulliparous ones. The association was, however, substantially diminished by adjustment for education and other CMM risk correlates (OR for at least three children versus none = 0.62; 95% Cl: 0.29-1.31).
通过在意大利西北部的都灵进行的一项基于人群的病例对照研究，探讨了激素和生殖因素作为皮肤恶性黑色素瘤（CMM）风险因素的作用。该研究涉及186例女性CMM病例和205名对照。既往口服避孕药（OC）的使用似乎对CMM风险比值比（OR）没有任何影响（OR = 1.12，95%置信区间（CI）：0.56 - 2.24）。即使对于最长使用时间、浅表扩散型黑色素瘤病例以及仅下肢的CMM病例，也未发现关联。虽然初产年龄不影响CMM风险，但与未生育的女性相比，生育三个或更多孩子的女性似乎受到显著保护。然而，通过对教育程度和其他CMM风险相关因素进行调整后，这种关联显著减弱（至少三个孩子与无孩子相比的OR = 0.62；95% CI：0.29 - 1.31）。
