Gallagher R P, Elwood J M, Hill G B, Coldman A J, Threlfall W J, Spinelli J J
Br J Cancer. 1985 Dec;52(6):901-7. doi: 10.1038/bjc.1985.275.
A study of 361 female melanoma patients and age matched controls was conducted in the four western provinces of Canada. Analysis of reproductive factors showed a significant negative association between number of livebirths and risk of melanoma. The relationship persisted for superficial spreading melanomas after adjustment for host pigmentation factors, freckling, and educational status. An inverse association between bilateral oophorectomy and risk of superficial spreading melanoma was also seen. No association was found between risk of melanoma and age at first birth, age at menarche and age at natural menopause. No association was found between risk of superficial spreading or nodular melanoma and use of either oral contraceptives or menopausal oestrogens.
在加拿大西部的四个省份对361名女性黑色素瘤患者及年龄匹配的对照组进行了一项研究。生殖因素分析显示，活产数与黑色素瘤风险之间存在显著负相关。在调整宿主色素沉着因素、雀斑和教育程度后，这种关系在浅表扩散性黑色素瘤中依然存在。双侧卵巢切除术与浅表扩散性黑色素瘤风险之间也存在负相关。未发现黑色素瘤风险与初产年龄、月经初潮年龄和自然绝经年龄之间存在关联。未发现浅表扩散性或结节性黑色素瘤风险与口服避孕药或绝经后雌激素的使用之间存在关联。
