International Agency for Research on Cancer, Lyon, France.
Cancer Causes Control. 2012 Jul;23(7):1149-62. doi: 10.1007/s10552-012-9984-z. Epub 2012 May 24.
Epidemiologic studies have suggested that higher levels of circulating vitamin D may reduce breast cancer risk, but no studies have investigated this association among women in developing countries, and very few studies have further investigated this association according to menopausal status.
A population-based case-control study in Mexico with 1,000 incident breast cancer cases aged 35-69 years, enrolled shortly after diagnosis (0-6 days) and frequency-matched to 1,074 controls on age, region, and health care system, was used to assess the association between serum 25-hydroxyvitamin D [25(OH)D] levels with overall, pre- and postmenopausal breast cancer risk. 25(OH)D concentration was measured on a random sub-sample of women (573 cases and 639 matched controls) using a liquid chromatography/tandem mass spectrometry method. Odds ratios (ORs) and 95 % confidence intervals (CIs) were estimated from multivariable conditional logistic regression models.
Serum 25(OH)D concentration (per 10 ng/mL increase) showed a strong inverse association with risk of breast cancer among all (p(trend) = 0.001), pre- (p(trend) = 0.006) and postmenopausal women (p(trend) = 0.0001). Compared with a predefined lower concentration of 25(OH)D (<20 ng/mL), higher levels (>30 ng/mL) were associated with lower overall (OR = 0.53, 95 % CI: 0.28-1.00; p(trend) = 0.002), pre- (OR = 0.60, 95 % CI: 0.16-2.17; p(trend) = 0.07) and postmenopausal (OR = 0.37, 95 % CI: 0.16-0.82; p(trend) = 0.004) breast cancer risk.
The results of this large population-based case-control study indicate an inverse association between circulating vitamin D levels and breast cancer risk among pre- and postmenopausal Mexican women.
流行病学研究表明，循环维生素 D 水平较高可能降低乳腺癌风险，但在发展中国家的女性中尚未有研究调查这种关联，而且根据绝经状态进一步调查这种关联的研究很少。
在墨西哥进行了一项基于人群的病例对照研究，共纳入 1000 例年龄在 35-69 岁的新发乳腺癌患者，在诊断后不久（0-6 天）进行入组，并按年龄、地区和医疗保健系统与 1074 名对照进行频数匹配。使用液相色谱/串联质谱法对随机抽取的女性亚组（573 例病例和 639 例匹配对照）测量血清 25-羟维生素 D [25(OH)D] 水平，评估血清 25(OH)D 水平与总体、绝经前和绝经后乳腺癌风险之间的关联。使用多变量条件逻辑回归模型估计比值比（OR）和 95%置信区间（CI）。
血清 25(OH)D 浓度（每增加 10ng/mL）与所有乳腺癌患者的风险呈强烈负相关（趋势 P 值=0.001）、绝经前（趋势 P 值=0.006）和绝经后女性（趋势 P 值=0.0001）。与较低的 25(OH)D 浓度（<20ng/mL）相比，较高的水平（>30ng/mL）与总体乳腺癌（OR=0.53，95%CI：0.28-1.00；趋势 P 值=0.002）、绝经前乳腺癌（OR=0.60，95%CI：0.16-2.17；趋势 P 值=0.07）和绝经后乳腺癌（OR=0.37，95%CI：0.16-0.82；趋势 P 值=0.004）风险降低相关。
这项大型基于人群的病例对照研究的结果表明，循环维生素 D 水平与墨西哥绝经前和绝经后女性的乳腺癌风险之间呈负相关。
