van Dongen P A, Broekkamp C L, Cools A R
Brain Res Bull. 1979 May-Jun;4(3):307-11. doi: 10.1016/s0361-9230(79)80006-4.
Cats pretreated with morphine (5 mg/kg, IP) received naloxone into the area of the locus coeruleus (LC) or the area of the substantia nigra (SN). The LC-treated animals stopped the morphine-induced stereotyped behavior and showed normal but hyperactive behavior. The SN-treated animals, however, ceased their movements of the head and the forelegs, adopted a rigid posture with extended forelegs and became hypoactive. It is concluded that both the LC area, which contains noradrenergic cell bodies, and the SN area, which contains dopaminergic cell bodies, are sites of action of morphine on behavior.
用吗啡（5毫克/千克，腹腔注射）预处理的猫，在蓝斑（LC）区域或黑质（SN）区域注射纳洛酮。接受LC区域注射的动物停止了吗啡诱导的刻板行为，并表现出正常但多动的行为。然而，接受SN区域注射的动物停止了头部和前肢的运动，采取了前肢伸展的僵硬姿势，并变得活动减少。得出的结论是，含有去甲肾上腺素能细胞体的LC区域和含有多巴胺能细胞体的SN区域都是吗啡对行为的作用部位。
