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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Eison M S, Ellison G

Gen Pharmacol. 1982;13(5):407-12. doi: 10.1016/0306-3623(82)90106-9.

Slow-release silicone pellets containing d-amphetamine base were implanted subcutaneously in rats 20 days following radio-frequency lesions of the locus coeruleus (LC), substantia nigra (SN), or control operations. 2. LC-lesioned rats exhibited enhanced motor stereotypies soon after implantation, while SN-lesioned animals showed increased locomotion but decreased stereotypy and anorexia. 3. The later behavioral stages of continuous amphetamine intoxication were attenuated in both lesioned groups as controls then entered the most intense stereotypy, showed the greatest withdrawal to the burrows, and maximally exhibited the increase in socially disruptive behaviors which appear following four days of constant amphetamine intoxication. 4. The integrity of both dopaminergic and noradrenergic systems was necessary for the full expression of the late stages of this animal model of amphetamine psychosis.

在对大鼠蓝斑（LC）、黑质（SN）进行射频损伤或假手术20天后，将含有d - 苯丙胺碱的缓释硅胶微丸皮下植入大鼠体内。2. LC损伤的大鼠在植入后不久就表现出运动刻板行为增强，而SN损伤的动物则表现出运动增加，但刻板行为减少且出现厌食。3. 两个损伤组中，苯丙胺持续中毒后期的行为阶段均有所减弱，此时对照组进入最强烈的刻板行为阶段，表现出对洞穴的最大回避，并最大程度地表现出在持续苯丙胺中毒四天后出现的社会破坏性行为增加。4. 多巴胺能和去甲肾上腺素能系统的完整性对于这种苯丙胺精神病动物模型后期阶段的充分表现是必要的。

Eison M S, Ellison G

Gen Pharmacol. 1982;13(5):407-12. doi: 10.1016/0306-3623(82)90106-9.

Slow-release silicone pellets containing d-amphetamine base were implanted subcutaneously in rats 20 days following radio-frequency lesions of the locus coeruleus (LC), substantia nigra (SN), or control operations. 2. LC-lesioned rats exhibited enhanced motor stereotypies soon after implantation, while SN-lesioned animals showed increased locomotion but decreased stereotypy and anorexia. 3. The later behavioral stages of continuous amphetamine intoxication were attenuated in both lesioned groups as controls then entered the most intense stereotypy, showed the greatest withdrawal to the burrows, and maximally exhibited the increase in socially disruptive behaviors which appear following four days of constant amphetamine intoxication. 4. The integrity of both dopaminergic and noradrenergic systems was necessary for the full expression of the late stages of this animal model of amphetamine psychosis.

在对大鼠蓝斑（LC）、黑质（SN）进行射频损伤或假手术20天后，将含有d - 苯丙胺碱的缓释硅胶微丸皮下植入大鼠体内。2. LC损伤的大鼠在植入后不久就表现出运动刻板行为增强，而SN损伤的动物则表现出运动增加，但刻板行为减少且出现厌食。3. 两个损伤组中，苯丙胺持续中毒后期的行为阶段均有所减弱，此时对照组进入最强烈的刻板行为阶段，表现出对洞穴的最大回避，并最大程度地表现出在持续苯丙胺中毒四天后出现的社会破坏性行为增加。4. 多巴胺能和去甲肾上腺素能系统的完整性对于这种苯丙胺精神病动物模型后期阶段的充分表现是必要的。