HIV-1 gp120 V1/V2 区的一小段是对 V1/V2 中和抗体产生耐药性的主要决定因素。
A short segment of the HIV-1 gp120 V1/V2 region is a major determinant of resistance to V1/V2 neutralizing antibodies.
机构信息
Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
出版信息
J Virol. 2012 Aug;86(15):8319-23. doi: 10.1128/JVI.00696-12. Epub 2012 May 23.
Abstract
Antibody PG9 is a prototypical member of a class of V1/V2-directed antibodies that effectively neutralizes diverse strains of HIV-1. We analyzed strain-specific resistance to PG9 using sequence and structural information. For multiply resistant strains, mutations in a short segment of V1/V2 resulted in gain of sensitivity to PG9 and related V1/V2 neutralizing antibodies, suggesting both a common mechanism of HIV-1 resistance to and a common mode of recognition by this class of antibodies.
摘要
抗体 PG9 是一类 V1/V2 定向抗体的典型代表，能有效中和多种 HIV-1 毒株。我们利用序列和结构信息分析了对 PG9 的株特异性耐药性。对于多重耐药株，V1/V2 短片段中的突变导致对 PG9 和相关 V1/V2 中和抗体的敏感性增加，提示 HIV-1 对此类抗体的耐药性和识别模式存在共同机制。
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