Eisen E J, Coffey M T
Dept. of Anim. Sci., North Carolina State University, Raleigh 27695-7621.
J Anim Sci. 1990 Nov;68(11):3557-62. doi: 10.2527/1990.68113557x.
Correlated responses in whole-body composition were determined in 12-wk-old male mice from replicate lines selected for 12 generations for high (HF) or low (LF) epididymal fat pad weight as a percentage of body weight (EPID) and high (HL) or low (LL) hind carcass weight as a percentage of body weight. The HF and LF lines diverged (P less than .01) in body fat percentage (FAT) and subcutaneous depot fat by 93 and 71%, respectively, of the control line (RC) mean. EPID increased (P less than .01) proportionately more than FAT in the HF line; EPID decreased (P less than .01) proportionately less than FAT in LF. Protein, fat and water as a percentage of empty body weight showed negative correlated responses (P less than .01) due to selection for EPID, but lean body mass, body weight and body length had positive correlated responses (P less than .01). Correlated responses of fat-free protein and ash percentage were minor. Correlated responses in HL and LL were the mirror images of those in HF and LF, but they generally were of smaller magnitude. The results indicate that, although there are high positive genetic correlations between fat depots in mice, local control of lipogenesis and(or) lipolysis exists at different sites of fat deposition. Further, the lack of correlated responses in fat-free percentage of protein (and percentage of ash) suggests that additive genetic variances are low for these traits and(or) the genetic correlations of these traits with the selection criteria are low.
对12周龄雄性小鼠的全身成分相关反应进行了测定，这些小鼠来自经过12代选育的重复品系，选育指标为附睾脂肪垫重量占体重的百分比（EPID）高（HF）或低（LF），以及后躯胴体重量占体重的百分比高（HL）或低（LL）。HF和LF品系在体脂百分比（FAT）和皮下脂肪库脂肪方面分别比对照品系（RC）均值高93%和71%，差异显著（P小于0.01）。在HF品系中，EPID的增加比例（P小于0.01）比FAT更大；在LF品系中，EPID的减少比例（P小于0.01）比FAT更小。以空腹体重的百分比表示的蛋白质、脂肪和水分呈现出因对EPID的选择而产生的负相关反应（P小于0.01），但瘦体重、体重和体长呈现正相关反应（P小于0.01）。无脂蛋白质和灰分百分比的相关反应较小。HL和LL品系的相关反应与HF和LF品系的相反，但总体幅度较小。结果表明，尽管小鼠脂肪库之间存在高度正遗传相关性，但脂肪生成和（或）脂肪分解在不同脂肪沉积部位存在局部调控。此外，无脂蛋白质百分比（和灰分百分比）缺乏相关反应表明，这些性状的加性遗传方差较低，且（或）这些性状与选择标准的遗传相关性较低。
