选择体成分特征的小鼠脂肪沉积发育和分布的相关反应。

Correlated responses in development and distribution of fat depots in mice selected for body composition traits.

机构信息

Animal Science Department, North Carolina State University, 27695-7621, Raleigh, NC, USA.

出版信息

Theor Appl Genet. 1989 Aug;78(2):217-23. doi: 10.1007/BF00288802.

Abstract

Development of adipose tissue in five depots was investigated in mice selected for high or low 12-week epididymal fat pad weight as a percentage of body weight (HF and LF lines), or high or low 12-week hind carcass weight as a percentage of body weight (HL and LL lines). An unselected control line (RC) was maintained. Hind carcass (HC) and fat pads from subcutaneous hindlimb, subcutaneous forelimb, gonads, kidneys and mesentery were dissected and weighed at 4, 6, 9, 12 or 15 weeks of age. Generally, body weight (BW), daily gain (DG), feed intake (FI), feed efficiency (FE) and feed intake/metabolic body weight (FC) were higher (P≤0.05) in HF than in LF, and in LL than in HL. HF had more fat (as a percentage of BW) than LF in all depots (P≲-0.01), and asymmetry (P≤0.01) was detected for gonadal fat. LL consistently had a higher (P≤0.01) fat percentage than HL, and asymmetry (P≤0.01) was observed for perirenal fat. At age of selection, ranking of fat depot weights as a percentage of total fat depot weight was not changed by selection; however, gonadal fat accounted for more of the total fat in HF and LL compared with RC, while the opposite was found in LF and HL. HC percentage was higher (P≤0.01) in HL than LL, and higher (P≤0.01) in LF than HF. Growth rate of each fat depot relative to BW was not affected by selection. These results demonstrated that selection for proportion of fat in one depot or for HC percentage changed fat percentage in other depots. However, the rate of fat deposition in each depot relative to body weight gain was not altered.

摘要

选择体重为附睾脂肪垫重量百分比（HF 和 LF 系）或体重为后躯体重百分比（HL 和 LL 系）高或低的小鼠，研究了五个脂肪组织的发育。维持未选择的对照系（RC）。在 4、6、9、12 或 15 周龄时，解剖和称重后躯（HC）和后肢皮下脂肪垫、前肢皮下脂肪垫、性腺、肾脏和肠系膜。通常，HF 比 LF 体重（BW）、日增重（DG）、饲料摄入量（FI）、饲料效率（FE）和饲料摄入量/代谢体重（FC）更高（P≤0.05），而 LL 比 HL 更高（P≤0.05）。HF 在所有部位的脂肪（占 BW 的百分比）比 LF 更高（P≲-0.01），并检测到性腺脂肪的不对称性（P≤0.01）。LL 始终比 HL 有更高的脂肪百分比（P≤0.01），并且观察到肾周脂肪的不对称性（P≤0.01）。在选择时，作为总脂肪储存重量百分比的脂肪储存重量的排名没有因选择而改变；然而，与 RC 相比，HF 和 LL 中的性腺脂肪占总脂肪的比例更高，而 LF 和 HL 则相反。HL 中的 HC 百分比高于 LL（P≤0.01），而 LF 高于 HF（P≤0.01）。相对于 BW 的每个脂肪储存的生长速度不受选择的影响。这些结果表明，选择一个储存部位的脂肪比例或选择 HC 百分比改变了其他储存部位的脂肪百分比。然而，相对于体重增加的每个储存部位的脂肪沉积率没有改变。