印度西部一株 23 型蓝舌病毒重组毒株的基因组序列。
Genome sequence of a reassortant strain of bluetongue virus serotype 23 from western India.
机构信息
Vector-Borne Diseases Programme, Institute for Animal Health, Pirbright, Woking Surrey, United Kingdom.
出版信息
J Virol. 2012 Jun;86(12):7011-2. doi: 10.1128/JVI.00731-12.
The full genome sequence (19,177 bp) of an Indian strain (IND1988/02) of bluetongue virus (BTV) serotype 23 was determined. This virus was isolated from a sheep that had been killed during a severe bluetongue outbreak that occurred in Rahuri, Maharashtra State, western India, in 1988. Phylogenetic analyses of these data demonstrate that most of the genome segments from IND1988/02 belong to the major "eastern" BTV topotype. However, genome segment 5 belongs to the major "western" BTV topotype, demonstrating that IND1988/02 is a reassortant. This may help to explain the increased virulence that was seen during this outbreak in 1988. Genome segment 5 of IND1988/02 shows >99% sequence identity with some other BTV isolates from India (e.g., BTV-3 IND2003/08), providing further evidence of the existence and circulation of reassortant strains on the subcontinent.
印度 1988 年爆发蓝舌病疫情时，从马哈拉施特拉邦拉胡里（Rahuri）地区死亡的绵羊中分离到一株血清 23 型蓝舌病病毒（BTV）印度株（IND1988/02），并测定了其全基因组序列（19177bp）。这些数据的系统进化分析表明，IND1988/02 的大部分基因组片段属于主要的“东部”BTV 拓扑型，但基因组 5 片段属于主要的“西部”BTV 拓扑型，表明 IND1988/02 是重组体。这可能有助于解释 1988 年疫情期间观察到的毒力增强现象。IND1988/02 的基因组 5 片段与印度的其他一些 BTV 分离株（如 BTV-3 IND2003/08）的序列同源性>99%，进一步证实了重组体在该次大陆的存在和传播。
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