Kar Sumit, Krishnan Ajay, Preetha K, Mohankar Atul
Department of Dermatology, Venereology and Leprosy, Mahatma Gandhi Institute of Medical Sciences, Sewagram, Wardha, Maharashtra, India.
J Pharmacol Pharmacother. 2012 Apr;3(2):105-8. doi: 10.4103/0976-500X.95503.
Antihistamines are one of the most common drugs that are used extensively in various dermatological and nondermatological conditions. The use of H-1-antihistamines during pregnancy has been very controversial due to possible teratogenic effects of these drugs. None of the antihistamines available today have been categorized as safe during pregnancy. Control studies are available for certain first generation drugs regarding their safety in pregnancy, but the newer agents require further studies to be declared safer in pregnancy. A few drugs are comparatively safer to use in pregnancy than others. Every drug used in pregnancy carries a risk for teratogenicity and careful risk/benefit assessment should be done before prescribing them.
抗组胺药是在各种皮肤病和非皮肤病病症中广泛使用的最常见药物之一。由于这些药物可能具有致畸作用，孕期使用H-1抗组胺药一直存在很大争议。目前可用的抗组胺药均未被归类为孕期安全用药。对于某些第一代药物，已有关于其孕期安全性的对照研究，但新型药物需要进一步研究才能宣称在孕期更安全。有几种药物在孕期使用相对比其他药物更安全。孕期使用的每种药物都有致畸风险，在开处方前应进行仔细的风险/效益评估。
