Department of Neurology, University of Magdeburg, Magdeburg, Germany.
PLoS One. 2012;7(5):e36572. doi: 10.1371/journal.pone.0036572. Epub 2012 May 22.
The influence of bilateral deep brain stimulation (DBS) of the nucleus nucleus (NAcc) on the processing of reward in a gambling paradigm was investigated using H(2)[(15)O]-PET (positron emission tomography) in a 38-year-old man treated for severe alcohol addiction. Behavioral data analysis revealed a less risky, more careful choice behavior under active DBS compared to DBS switched off. PET showed win- and loss-related activations in the paracingulate cortex, temporal poles, precuneus and hippocampus under active DBS, brain areas that have been implicated in action monitoring and behavioral control. Except for the temporal pole these activations were not seen when DBS was deactivated. These findings suggest that DBS of the NAcc may act partially by improving behavioral control.
采用 H(2)[(15)O]-PET（正电子发射断层扫描）技术，研究了双侧伏隔核（NAcc）深部脑刺激（DBS）对赌博范式中奖励处理的影响，该技术在一名 38 岁男性中进行，该男性患有严重的酒精成瘾症。行为数据分析显示，与 DBS 关闭相比，在主动 DBS 下患者的选择行为风险较低，更加谨慎。PET 显示，在主动 DBS 下，与输赢相关的激活出现在旁扣带皮层、颞极、楔前叶和海马体中，这些区域与动作监测和行为控制有关。除了颞极之外，当 DBS 失活时，这些激活就不会出现。这些发现表明，NAcc 的 DBS 可能部分通过改善行为控制来发挥作用。
