Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, Shimotsuke, Tochigi, Japan.
Clin Exp Hypertens. 2013;35(1):40-4. doi: 10.3109/10641963.2012.689044. Epub 2012 May 25.
The aim of this study was to compare the differences in the levels of a highly sensitive cardiac troponin T (Hs-cTnT) between Losartan (LOS) plus hydrochlorothiazide (HCTZ) and amlodipine. Seventy-eight hypertensive patients were randomized to receive LOS/HCTZ or amlodipine for 8 weeks. Both treatments decreased clinic and 24-hour blood pressure to the same extent. The Hs-cTnT level was significantly reduced in the amlodipine group (P < .05), but such a reduction was not found in the LOS/HCTZ group in the upper half group of Hs-cTnT level at baseline. Amlodipine had a more beneficial effect than LOS/HCTZ in patients with high Hs-cTnT levels.
本研究旨在比较氯沙坦（LOS）加氢氯噻嗪（HCTZ）与氨氯地平之间高敏心肌肌钙蛋白 T（Hs-cTnT）水平的差异。78 例高血压患者随机接受 LOS/HCTZ 或氨氯地平治疗 8 周。两种治疗均使诊室和 24 小时血压降低到相同程度。氨氯地平组 Hs-cTnT 水平显著降低（P <.05），但在基线 Hs-cTnT 水平较高的上半部分患者中，LOS/HCTZ 组未发现这种降低。在 Hs-cTnT 水平较高的患者中，氨氯地平的疗效优于氯沙坦。
