Department of Medical Microbiology and Parasitology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang 43400, Selangor, Malaysia.
J Hosp Infect. 2012 Jul;81(3):206-8. doi: 10.1016/j.jhin.2012.04.015. Epub 2012 May 26.
The minimum inhibitory concentrations (MICs) of 60 meticillin-resistant Staphylococcus aureus (MRSA) isolates from Malaysia to three antiseptic agents - benzalkonium chloride (BZT), benzethonium chloride (BAC) and chlorhexidine digluconate (CHG) - were determined. All isolates had MICs ranging from 0.5 to 2 mg/L. Antiseptic resistance genes qacA/B and smr were detected in 83.3% and 1.6% of the isolates, respectively. Carriage of qacA/B correlated with reduced susceptibility to CHG and BAC. This is the first report of the prevalence of qacA/B and smr gene carriage in Malaysian MRSA isolates, with a high frequency of qacA/B carriage. The presence of these antiseptic resistance genes and associated reduced susceptibility to antiseptic agents may have clinical implications.
从马来西亚分离的 60 株耐甲氧西林金黄色葡萄球菌（MRSA）对三种防腐剂 - 苯扎氯铵（BZT）、苯扎溴铵（BAC）和葡萄糖酸氯己定（CHG）的最低抑菌浓度（MICs）进行了测定。所有分离株的 MIC 范围为 0.5 至 2mg/L。分别在 83.3%和 1.6%的分离株中检测到防腐剂耐药基因 qacA/B 和 smr。qacA/B 的携带与对 CHG 和 BAC 的敏感性降低相关。这是马来西亚 MRSA 分离株中 qacA/B 和 smr 基因携带率的首次报道，qacA/B 的携带率很高。这些防腐剂耐药基因的存在以及与防腐剂敏感性降低相关，可能具有临床意义。
