FHI 360, Research Triangle Park, NC 27709, USA.
Contraception. 2012 Nov;86(5):511-7. doi: 10.1016/j.contraception.2012.04.013. Epub 2012 May 26.
Subdermal contraceptive implants have low discontinuation rates but are underused among young women in Africa. This study aimed to isolate the role initial contraceptive method has on preventing unintended pregnancy.
We recruited 399 Kenyan women aged 18-24 years into a prospective cohort study if they wanted short-acting hormonal methods (injectable or oral contraceptives). We offered an implant and formed two study groups: implant and short-acting. For contraceptive discontinuation/pregnancy, we used log-rank tests and proportional hazards models. We applied intent-to-treat principles to evaluate the role of initial method choice on future pregnancy.
Twenty-four percent opted for an implant (n=97), and the remainder opted for a short-acting method (n=299). The 18-month discontinuation probability was 21 per 100 for implant users and 43 per 100 for the short-acting method group (p=.001). Twenty-two unintended pregnancies occurred; all were among the short-acting group. The adjusted relative risk of pregnancy among the short-acting group vs. implant group was 7.4 (95% confidence interval: 1.6-34.5).
Many young Kenyan women found implants to be a reasonable alternative to short-acting methods. Having choice is essential, and starting on implants provides substantial and clear protection from unintended pregnancy relative to short-acting methods.
皮下埋植避孕法的中断率较低,但在非洲年轻女性中使用率较低。本研究旨在确定初始避孕方法对预防意外怀孕的作用。
我们招募了 399 名年龄在 18-24 岁的肯尼亚女性,如果她们想要使用短效激素方法(注射或口服避孕药),则将其纳入前瞻性队列研究。我们提供了一种植入物,并将其分为两组:植入物组和短效组。对于避孕方法的停用/怀孕,我们使用对数秩检验和比例风险模型。我们采用意向治疗原则来评估初始方法选择对未来怀孕的影响。
24%的人选择了植入物(n=97),其余的人选择了短效方法(n=299)。植入物组的 18 个月停用率为每 100 人中有 21 人,而短效组的停用率为每 100 人中有 43 人(p=0.001)。发生了 22 例意外怀孕,均发生在短效组。与植入物组相比,短效组意外怀孕的调整后相对风险为 7.4(95%置信区间:1.6-34.5)。
许多肯尼亚年轻女性发现植入物是一种替代短效方法的合理选择。有选择是很重要的,与短效方法相比,开始使用植入物可以提供实质性和明确的保护,防止意外怀孕。