Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, School of Life Sciences, Southwest University, Beibei, Chongqing 400715, China.
Cell Signal. 2012 Sep;24(9):1841-6. doi: 10.1016/j.cellsig.2012.05.014. Epub 2012 May 23.
The 6kDa early secreted antigenic target (ESAT-6), an important and intensively studied virulence factor of Mycobacterium tuberculosis, acts alone or in combination with CFP-10 to influence the outcome of the host-pathogen interaction. Secreted ESAT-6 can disturb the activation of macrophages, induce apoptosis and subvert host immunity. ESAT-6 mediated autophagosome formation and TLR signaling deviation lead to abnormal activation of NF-κB and subsequent erroneous expression of NF-κB-dependent genes. The C-terminal amino acid residues 90-95 in ESAT-6 are essential for the interaction with host. In-depth appreciation of the multiple roles of ESAT-6 upon host can inform improvements for novel vaccines and diagnostic tools for tuberculosis.
6kDa 早期分泌抗原靶标（ESAT-6）是结核分枝杆菌的一个重要且深入研究的毒力因子，单独或与 CFP-10 联合作用，影响宿主-病原体相互作用的结果。分泌的 ESAT-6 可干扰巨噬细胞的激活，诱导细胞凋亡并颠覆宿主免疫。ESAT-6 介导的自噬体形成和 TLR 信号转导偏差导致 NF-κB 的异常激活，随后 NF-κB 依赖性基因的错误表达。ESAT-6 中 C 末端氨基酸残基 90-95 对于与宿主的相互作用是必需的。深入了解 ESAT-6 对宿主的多种作用，可以为结核病的新型疫苗和诊断工具提供改进。
