Kefeli Mehmet, Baris Sancar, Aydin Oguz, Yıldız Levent, Yamak Seda, Kandemir Bedri
Department of Pathology, Ondokuz Mayis University, Medical School, Gazi State Hospital, Samsun, Turkey.
Ann Saudi Med. 2012 Sep-Oct;32(5):544-6. doi: 10.5144/0256-4947.2012.23.5.1111.
Leiomyoma is the most common uterine neoplasm. It has several histological variants such as atypical, cellular, myxoid, and epithelioid. Leiomyoma with heterologous elements is a rare variant of leiomyoma, which may contain heterologous elements such as fat, skeletal muscle, and chondroid and osseous tissues. The heterologous sarcomatous differentiation is also rarely seen. We report on a 53-year-old woman who was admitted with abnormal vaginal bleeding and symptoms related to an abdominal mass. She had a huge uterine leiomyoma that contained osteosarcomatous differentiation in several foci. Although malignant progression for leiomyoma is exceedingly rare, when it occurs it may result not only in a leiomyosarcoma but also in a heterologous sarcomatous differention. We have reported histopathological, immunohistochemical, and clinical features of this rare case and reviewed the published studies.
平滑肌瘤是最常见的子宫肿瘤。它有几种组织学变体，如非典型、富于细胞性、黏液样和上皮样。含有异源性成分的平滑肌瘤是平滑肌瘤的一种罕见变体，其可能包含脂肪、骨骼肌、软骨样和骨组织等异源性成分。异源性肉瘤样分化也很少见。我们报告了一名53岁女性，她因异常阴道出血及与腹部肿块相关的症状入院。她患有巨大的子宫平滑肌瘤，在几个病灶中含有骨肉瘤样分化。虽然平滑肌瘤的恶性进展极为罕见，但一旦发生，不仅可能导致平滑肌肉瘤，还可能导致异源性肉瘤样分化。我们报告了这一罕见病例的组织病理学、免疫组化和临床特征，并对已发表的研究进行了综述。
