Department of Pharmacy, Xuzhou Medical College, Jiangsu, China.
Environ Toxicol Pharmacol. 2012 Sep;34(2):280-287. doi: 10.1016/j.etap.2012.04.009. Epub 2012 May 11.
We examined the protective effect of l-citrulline on ethanol-induced gastric ulcer in rats. Administration of l-citrulline at doses of 300, 600 and 900mg/kg body weight prior to ethanol ingestion protected the stomach from ulceration. The gastric lesions were significantly attenuated by all doses of l-citrulline as compared to the ethanol group. Pre-treatment with l-citrulline prevented the oxidative damage and the decrease of nitric oxide content as well as the increase of the myeloperoxidase activity. Consequently, significant changes observed included the attenuation in the elevation in total nitric oxide synthase activity and inducible nitric oxide synthase activity as well as the decrease in constitutive nitric oxide synthase activity in the gastric mucosa induced by ethanol. Analysis of serum cytokines of ethanol-induced rats showed a moderate decrease in interleukin-10 with considerable increase of interleukin-6 while l-citrulline inhibited the acute alteration of cytokines. These results suggested the gastroprotective effect of l-citrulline.
我们研究了 l-瓜氨酸对乙醇诱导的大鼠胃溃疡的保护作用。在摄入乙醇之前，以 300、600 和 900mg/kg 体重的剂量给予 l-瓜氨酸，可以保护胃免受溃疡。与乙醇组相比，所有剂量的 l-瓜氨酸均可显著减轻胃损伤。l-瓜氨酸预处理可预防氧化损伤和一氧化氮含量降低，以及髓过氧化物酶活性增加。因此，观察到的显著变化包括乙醇诱导的总一氧化氮合酶活性和诱导型一氧化氮合酶活性升高以及胃黏膜固有型一氧化氮合酶活性降低的减弱。对乙醇诱导的大鼠血清细胞因子的分析表明，白细胞介素-10 适度降低，白细胞介素-6 显著增加，而 l-瓜氨酸抑制了细胞因子的急性改变。这些结果表明 l-瓜氨酸具有胃保护作用。
