Jaspers R M, Cools A R
Psychoneuropharmacological Research Unit, University of Nijmegen, The Netherlands.
Pharmacol Biochem Behav. 1990 Sep;37(1):1-9. doi: 10.1016/0091-3057(90)90034-f.
Intracaudate injections of relatively high doses of apomorphine produce a regression in motor behavior of cats collecting food pellets in a treadmill design (25). It has been hypothesized that this regression is partly due to functional disturbances in brain regions receiving (in) directly striatal output signals. In view of this hypothesis it was investigated whether experimentally induced changes in GABAergic activity within the deeper layers of the colliculus superior, which is a second order output station of the caudate nucleus, are also able to elicit a regression in motor behavior. Therefore, motor behavior of cats was tested in the treadmill paradigm before and after intracollicular injections of the GABA antagonist picrotoxin. Picrotoxin produced dose-dependently a regression in motor behavior which was comparable to that elicited by intrastriatally injected apomorphine. The noted effects were GABA-specific since muscimol attenuated the picrotoxin-induced regression. The present data are discussed in view of a model for a hierarchical organization of the brain.
在跑步机设计中，向猫的尾状核内注射相对高剂量的阿扑吗啡会导致其收集食物颗粒的运动行为出现退化（25）。据推测，这种退化部分是由于直接或间接接收纹状体输出信号的脑区功能紊乱所致。基于这一假设，研究了在实验中诱导尾状核的二级输出站——上丘深层内GABA能活性的变化是否也能引发运动行为的退化。因此，在向猫的上丘内注射GABA拮抗剂印防己毒素之前和之后，在跑步机范式中测试了猫的运动行为。印防己毒素剂量依赖性地导致运动行为退化，这与纹状体内注射阿扑吗啡所引发的退化相当。所观察到的效应具有GABA特异性，因为蝇蕈醇减弱了印防己毒素诱导的退化。本文根据大脑分层组织模型对这些数据进行了讨论。
