Gelissen M, Cools A
Department of Pharmacology, University of Nijmegen, The Netherlands.
Behav Brain Res. 1988 Jul;29(1-2):17-26. doi: 10.1016/0166-4328(88)90048-4.
Previous studies using various experimental set-ups, have shown that the dopaminergic activity in the caudate nucleus (CN) is involved in the organism's ability to switch from one motor or behavioural program to another without the help of external stimuli (switching arbitrarily). The main purpose of the present study was to investigate how arbitrarily switching motor patterns manifests itself in an 'open field situation'. Therefore, the effects of CN application of haloperidol (12.5 micrograms/5 microliter) and apomorphine (0.6 micrograms/5 microliter) were analyzed on the ability to switch from one motor program to any other program in cats habituated to an observation cage. Application of haloperidol decreased switching. In addition the number of distinct motor patterns declined after injecting haloperidol into the CN. The haloperidol-induced effect, however, was not selectively restricted to any particular motor pattern. Switching from one motor pattern to another increased after CN injection of apomorphine. Moreover, the number of distinct motor patterns increased after CN injection of apomorphine. However, the effect of CN application of apomorphine was not selectively restricted to any particular motor pattern. Since previous studies have demonstrated that various expressions of dopaminergic CN activity are funnelled through the deeper layers of the superior colliculus (dl-SC), it was hypothesized that switching induced by CN application of apomorphine may also be channelled through the dl-SC. Therefore the effect of dl-SC-injected muscimol (75 ng/1 microliter) was analyzed on the ability to switch motor programs in cats pretreated with apomorphine. Injection of muscimol into the dl-SC reduced both the number of distinct motor patterns and the number of switchings in cats pretreated with apomorphine.
以往使用各种实验装置进行的研究表明，尾状核（CN）中的多巴胺能活动参与了生物体在没有外部刺激帮助的情况下从一种运动或行为程序切换到另一种运动或行为程序的能力（任意切换）。本研究的主要目的是调查在“旷场情境”中任意切换运动模式是如何表现出来的。因此，分析了向CN注射氟哌啶醇（12.5微克/5微升）和阿扑吗啡（0.6微克/5微升）对习惯观察笼的猫从一种运动程序切换到任何其他程序的能力的影响。注射氟哌啶醇会减少切换。此外，向CN注射氟哌啶醇后，不同运动模式的数量减少。然而，氟哌啶醇诱导的效应并非选择性地局限于任何特定的运动模式。向CN注射阿扑吗啡后，从一种运动模式切换到另一种运动模式的情况增加。此外，向CN注射阿扑吗啡后，不同运动模式的数量增加。然而，向CN注射阿扑吗啡的效应并非选择性地局限于任何特定的运动模式。由于先前的研究表明，多巴胺能CN活动的各种表现形式是通过上丘深层（dl-SC）传导的，因此推测向CN注射阿扑吗啡诱导的切换也可能通过dl-SC传导。因此，分析了向dl-SC注射蝇蕈醇（75纳克/1微升）对用阿扑吗啡预处理的猫切换运动程序能力的影响。向dl-SC注射蝇蕈醇减少了用阿扑吗啡预处理的猫的不同运动模式数量和切换次数。
