Department of Neurosurgery, Nagoya University School of Medicine, Nagoya, Japan.
Adv Exp Med Biol. 2012;746:86-94. doi: 10.1007/978-1-4614-3146-6_7.
Cytokines are a heterogeneous group of soluble small polypeptides or glycoproteins, which exert pleiotropic and redundant effects that promote growth, differentiation and activation of normal cells. Cytokines can have either pro- or anti-inflammatory activity and immunosuppressive activity, depending on the microenvironments. The tumor microenvironment consists of a variable combination of tumor cells, endothelial cells and infiltrating leukocytes, such as macrophages, T-lymphocytes, natural killer (NK) cells, B cells and antigen-presenting cells (APCs). Cytokine production acts as a means of communication in the tumor microenvironment. In this article, we review the cross-talk between cytokines in the tumor environment and the cytokine therapies that have been used till date for glioma treatment.
细胞因子是一组异质的可溶性小分子多肽或糖蛋白，具有多效性和冗余效应，可促进正常细胞的生长、分化和激活。细胞因子根据微环境的不同，可以具有促炎或抗炎活性和免疫抑制活性。肿瘤微环境由肿瘤细胞、内皮细胞和浸润的白细胞（如巨噬细胞、T 淋巴细胞、自然杀伤（NK）细胞、B 细胞和抗原呈递细胞（APC））的可变组合组成。细胞因子的产生是肿瘤微环境中一种交流方式。在本文中，我们综述了肿瘤微环境中细胞因子之间的相互作用以及迄今为止用于治疗神经胶质瘤的细胞因子治疗。
