Iwami Kenichiro, Natsume Atsushi, Wakabayashi Toshihiko
Prog Neurol Surg. 2018;32:79-89. doi: 10.1159/000469682. Epub 2018 Jul 10.
Cytokines are a heterogeneous group of soluble small polypeptides or glycoproteins, which exert pleiotropic and redundant effects that promote growth, differentiation, and activation of cells. Cytokine production plays a profound role in the modulation of the tumor microenvironment, including the host of heterogeneous neoplastic cells, immune cells, and extracellular matrix, which is essential for progression of the neoplasm. Depending on specific conditions, the cytokines can either upregulate or downregulate anti-inflammatory and immunosuppressive activities. The crosstalk between cytokines and their receptors in the tumor microenvironment constitutes the target for various types of cytokine therapies that have been tested until now for treatment of patients with intracranial glioma.
细胞因子是一组异质性的可溶性小多肽或糖蛋白，它们发挥多效性和冗余性作用，促进细胞生长、分化和激活。细胞因子的产生在肿瘤微环境的调节中起着深远作用，肿瘤微环境包括多种异质性肿瘤细胞、免疫细胞和细胞外基质，这对肿瘤进展至关重要。根据特定条件，细胞因子可以上调或下调抗炎和免疫抑制活性。肿瘤微环境中细胞因子与其受体之间的相互作用构成了迄今为止已测试的各种细胞因子疗法治疗颅内胶质瘤患者的靶点。
