Centre for Neuroscience Studies, Queen's University, Kingston, Ontario, Canada, K7L 3N6.
Eur J Neurosci. 2012 Jun;35(11):1738-52. doi: 10.1111/j.1460-9568.2012.08079.x. Epub 2012 May 28.
Here we examined the influence of the visual response in the superior colliculus (SC) (an oculomotor control structure integrating sensory, motor and cognitive signals) on the development of the motor command that drives saccadic eye movements in monkeys. We varied stimulus luminance to alter the timing and magnitude of visual responses in the SC and examined how these changes correlated with resulting saccade behavior. Increasing target luminance resulted in multiple modulations of the visual response, including increased magnitude and decreased response onset latency. These signal modulations correlated strongly with changes in saccade latency and metrics, indicating that these signal properties carry through to the neural computations that determine when, where and how fast the eyes will move. Thus, components of the earliest part of the visual response in the SC provide important building blocks for the neural basis of the sensory-motor transformation, highlighting a critical link between the properties of the visual response and saccade behavior.
在这里，我们研究了上丘（SC）（整合感觉、运动和认知信号的眼球运动控制结构）中的视觉反应对驱动猴子扫视眼动的运动指令的发展的影响。我们改变了刺激亮度，以改变 SC 中的视觉反应的时间和幅度，并研究了这些变化与扫视行为的结果如何相关。增加目标亮度会导致视觉反应的多次调制，包括幅度增加和反应起始潜伏期减小。这些信号调制与扫视潜伏期和度量的变化密切相关，表明这些信号特性传递到确定眼睛何时、何地以及移动速度的神经计算中。因此，SC 中视觉反应最早部分的组成部分为感觉运动转换的神经基础提供了重要的构建块，突出了视觉反应特性和扫视行为之间的关键联系。
