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百草枯对组胺和异丙肾上腺素诱导的大鼠肺切片中环核苷酸变化的抑制作用。

The inhibitory effect of paraquat on histamine and isoproterenol induced changes of cyclic nucleotides in rat lung slices.

作者信息

Giri S N, Hollinger M A

出版信息

Experientia. 1979 Sep 15;35(9):1219-20. doi: 10.1007/BF01963300.

DOI:10.1007/BF01963300
PMID:226399
Abstract

The incubation of rat lung slices with paraquat ion (10(-4) M) had no effect on cAMP and cGMP levels of the rat lung slices. The preincubation with the same concentration of paraquat inhibited the cAMP elevating effect of histamine (10(-5) M) and isoproterenol (10(-5) M) and reduced the cGMP level to approximately 50% of the level obtained without preincubation with paraquat.

摘要

用百草枯离子(10⁻⁴M)孵育大鼠肺切片对其cAMP和cGMP水平没有影响。用相同浓度的百草枯预孵育可抑制组胺(10⁻⁵M)和异丙肾上腺素(10⁻⁵M)引起的cAMP升高作用,并使cGMP水平降低至未用百草枯预孵育时所获水平的约50%。

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本文引用的文献

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Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
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The pathogenesis and structure of paraquat-induced pulmonary fibrosis in rats.百草枯诱导大鼠肺纤维化的发病机制及结构
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Regulation by beta-adrenergic receptor and muscarinic cholinergic receptor activation of intracellular cyclic AMP and cyclic GMP levels in rat lung slices.
Biochem Biophys Res Commun. 1973 Dec 10;55(3):660-5. doi: 10.1016/0006-291x(73)91195-9.
4
Cyclic nucleotide-dependent protein kinases. X. An assay method for the measurement of quanosine 3',5'-monophosphate in various biological materials and a study of agents regulating its levels in heart and brain.环核苷酸依赖性蛋白激酶。X. 一种用于测量各种生物材料中3',5'-环磷酸鸟苷的测定方法以及对调节心脏和大脑中其水平的因子的研究。
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Characteristics of the hormonal induced cyclic adenosine 3',5'-monophosphate response in the rat and guinea pig lung in vitro.大鼠和豚鼠离体肺中激素诱导的环磷腺苷反应的特征
Biochim Biophys Acta. 1971 Dec 21;252(3):561-6. doi: 10.1016/0304-4165(71)90159-0.
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A simple, sensitive protein-binding assay for guanosine 3':5'-monophosphate.一种用于3':5'-环磷酸鸟苷的简单、灵敏的蛋白质结合测定法。
Proc Natl Acad Sci U S A. 1971 Apr;68(4):736-9. doi: 10.1073/pnas.68.4.736.
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Effects in vitro and in vivo of thioureas on acetylcholine esterase activity of rat tissues.硫脲对大鼠组织乙酰胆碱酯酶活性的体外和体内作用。
Biochem Pharmacol. 1977 Feb 15;26(4):313-7. doi: 10.1016/0006-2952(77)90183-6.
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A simple ultrasensitive method for the assay of cyclic AMP and cyclic GMP in tissues.
Life Sci. 1976 Mar 1;18(5):529-41. doi: 10.1016/0024-3205(76)90331-3.