百草枯对组胺和异丙肾上腺素诱导的大鼠肺切片中环核苷酸变化的抑制作用。
The inhibitory effect of paraquat on histamine and isoproterenol induced changes of cyclic nucleotides in rat lung slices.
作者信息
Giri S N, Hollinger M A
出版信息
Experientia. 1979 Sep 15;35(9):1219-20. doi: 10.1007/BF01963300.
PMID:226399
Abstract
The incubation of rat lung slices with paraquat ion (10(-4) M) had no effect on cAMP and cGMP levels of the rat lung slices. The preincubation with the same concentration of paraquat inhibited the cAMP elevating effect of histamine (10(-5) M) and isoproterenol (10(-5) M) and reduced the cGMP level to approximately 50% of the level obtained without preincubation with paraquat.
摘要
用百草枯离子（10⁻⁴M）孵育大鼠肺切片对其cAMP和cGMP水平没有影响。用相同浓度的百草枯预孵育可抑制组胺（10⁻⁵M）和异丙肾上腺素（10⁻⁵M）引起的cAMP升高作用，并使cGMP水平降低至未用百草枯预孵育时所获水平的约50%。
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