Department of Geriatric Endocrinology, Chinese PLA General Hospital, Beijing, China.
Aging Ment Health. 2012;16(7):911-4. doi: 10.1080/13607863.2012.688190. Epub 2012 May 29.
To evaluate the relationship of cognitive function with glucose tolerance status and obesity in Chinese middle-aged or aged adults.
A sample of 1722 subjects aged 40 years or order was investigated from four communities in Shijingshan District, Beijing, China. People with any emotional disorder, substance abuse, known diabetes or stroke were excluded. Global cognitive function was measured by the Mini-Mental State Examination (MMSE).
People with normal glucose tolerance showed higher mean MMSE scores compared to those with pre-diabetes or diabetes (p > 0.05 in males, p < 0.05 in females). People with ideal BMI (18.5-23.9) showed higher mean MMSE scores compared to those with BMI < 18.5 or BMI ≥ 24, but there was no statistical significance (p < 0.05) The significantly lower MMSE scores was shown in the groups with waist circumferences ≥ 85 cm in males, or ≥ 80 cm in females (p < 0.05). The multivariate linear regression analysis showed significant association of MMSE with waist circumferences, SBP, HDL-c and FPG (p=0.000, B=-0.179; p=0.000, B =-0.073; p=0.016, B=0.165; p=0.028, B=-0.124, respectively), except the association with age, education, economic income, smoking and alcohol intake.
In middle aged or aged residents, glucose tolerance status, obesity, and especially central obesity may be the important contributors to cognitive impairment.
评估认知功能与中国中老年人糖代谢状态和肥胖的关系。
本研究在北京石景山区四个社区中调查了 1722 名 40 岁及以上的受试者。排除任何情感障碍、物质滥用、已知糖尿病或中风的患者。采用简易精神状态检查（MMSE）评估总体认知功能。
与糖尿病前期或糖尿病患者相比，糖耐量正常者的 MMSE 评分均值更高（男性 p > 0.05，女性 p < 0.05）。与 BMI<18.5 或 BMI≥24 者相比，理想 BMI（18.5-23.9）者的 MMSE 评分均值更高，但差异无统计学意义（p < 0.05）。腰围男性≥85cm，或女性≥80cm者的 MMSE 评分显著降低（p < 0.05）。多元线性回归分析显示，MMSE 与腰围、SBP、HDL-c 和 FPG 显著相关（p=0.000，B=-0.179；p=0.000，B=-0.073；p=0.016，B=0.165；p=0.028，B=-0.124），与年龄、教育程度、经济收入、吸烟和饮酒无关。
在中老年人中，糖代谢状态、肥胖，尤其是中心性肥胖可能是认知障碍的重要原因。
