Division of Pediatric Neurology, Department of Pediatrics, Medical School of Patras, Patras, Greece.
Semin Pediatr Neurol. 2012 Mar;19(1):25-34. doi: 10.1016/j.spen.2012.02.013.
Approximately three-fourths of all pediatric cancer patients will be long-term survivors; however, there can be a steep cost for cancer survivorship. Cancer treatment involves exposure to chemotherapy, surgical intervention, and radiation, which can cause lasting long-term toxicities. Children with brain tumors have the highest prevalence of long-term morbidities. These effects can be attributed to direct neurologic damage to the developing brain caused by tumor, hydrocephalus, surgical removal of the tumor, and the effects of irradiation. The late effects experienced by childhood cancer survivors involve multiple domains, one of which is sleep disorders. Sleep dysfunction has an increased prevalence in the pediatric cancer survivor population. These issues are disruptive to patients and cause a decrease in quality of life. This review focuses on sleep disorders that occur in pediatric cancer survivors and discusses the possible causes, the assessments used to determine specific sleep disorders, and treatment modalities used to ameliorate this dysfunction with the hope of improving patient's quality of life.
大约四分之三的儿科癌症患者将成为长期幸存者；然而，癌症生存可能会带来高昂的代价。癌症治疗包括化疗、手术干预和放疗，这些治疗可能会导致持久的长期毒性。脑肿瘤患儿的长期发病率最高。这些影响可归因于肿瘤、脑积水、肿瘤切除手术和放疗对发育中大脑的直接神经损伤。儿童癌症幸存者所经历的晚期影响涉及多个领域，其中之一是睡眠障碍。儿科癌症幸存者人群中睡眠障碍的患病率增加。这些问题会对患者造成干扰，并导致生活质量下降。这篇综述重点介绍了儿科癌症幸存者中发生的睡眠障碍，并讨论了可能的原因、用于确定特定睡眠障碍的评估方法以及用于改善这种功能障碍的治疗方法，以期提高患者的生活质量。
