Vaughn Courtney M, Vaughn Bradley V
Department of Pediatrics, Division of Pediatric Hematology and Oncology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Department of Neurology, Division of Sleep Medicine, University of North Carolina, Chapel Hill, NC 27599, USA.
Cancers (Basel). 2025 Mar 7;17(6):911. doi: 10.3390/cancers17060911.
: Sleep issues are common in the general population, and these problems occur even more frequently for people with cancer. Sleep problems may pre-exist a patient's cancer diagnosis, and there is a growing interest in understanding the impact of sleep on cancer development and progression. Sleep disorders may impact cancer through altered metabolism, impacts on immune response, and alterations in hormones and gene expression. Sleep disorders may also arise after, or be aggravated by, an individual's cancer and cancer treatment. Treating a person with cancer's sleep disorder may help improve their healing, mental health, cognition, and overall resilience. Studies examining a variety of aspects of the relationship between sleep and cancer were found by searching the National Library of Medicine and characterized by their specific information provided on the relationship between sleep and cancer. This review article summarizes our current understanding of the complex inter-relationship between sleep and cancer, the underlying mechanisms that create these connections, and the methods and impact of treating sleep issues in cancer patients. The article also outlines an approach to sleep complaints for clinicians caring for patients with cancer. Significant research is still needed to understand the full relationship between sleep disorders and cancer. The impact of sleep issues on cancer and of cancer on sleep appears to be specific to the tissue and the molecular type of cancer. The treatment of sleep disorders is multimodal, and offers a promising avenue to improve the health and quality of life of cancer patients.
睡眠问题在普通人群中很常见，而这些问题在癌症患者中出现得更为频繁。睡眠问题可能在患者被诊断出癌症之前就已存在，并且人们对了解睡眠对癌症发生和发展的影响越来越感兴趣。睡眠障碍可能通过改变新陈代谢、影响免疫反应以及改变激素和基因表达来影响癌症。睡眠障碍也可能在个体患癌症和接受癌症治疗后出现或加重。治疗癌症患者的睡眠障碍可能有助于改善他们的愈合、心理健康、认知能力和整体恢复力。通过检索国立医学图书馆发现了研究睡眠与癌症之间关系各个方面的研究，并根据它们提供的关于睡眠与癌症关系的具体信息进行了描述。这篇综述文章总结了我们目前对睡眠与癌症之间复杂相互关系、建立这些联系的潜在机制以及治疗癌症患者睡眠问题的方法和影响的理解。文章还为照顾癌症患者的临床医生概述了处理睡眠问题的方法。仍需要大量研究来全面了解睡眠障碍与癌症之间的关系。睡眠问题对癌症的影响以及癌症对睡眠的影响似乎因癌症的组织和分子类型而异。睡眠障碍的治疗是多模式的，为改善癌症患者的健康和生活质量提供了一条有前景的途径。
