Department of Neurology, University Hospital Giessen and Marburg, Giessen, Germany.
Mult Scler. 2013 Jan;19(1):120-2. doi: 10.1177/1352458512445302. Epub 2012 May 28.
Baló's concentric sclerosis (BCS) is an inflammatory demyelinating disease related to multiple sclerosis; its underlying pathology remains unclear. At 7 T MRI in a 19-year-old female BCS patient, microhaemorrhages and ectatic veins were found in T2 hyperintense regions, features which have not been previously reported in conjunction with BCS, and these findings may support the view that vascular pathology plays a role in BCS. MRS data suggest that neuron loss and lipid turnover still took place months after a remission. Plasma exchange was effective in treating a relapse with severe motor deficits, and the off-label use of natalizumab was successful in maintaining remission in this patient.
巴洛氏同心性硬化症（BCS）是一种与多发性硬化症相关的炎症性脱髓鞘疾病，其潜在的病理机制尚不清楚。在一名 19 岁女性 BCS 患者的 7T MRI 中，T2 高信号区域发现了微出血和扩张静脉，这些特征以前与 BCS 并未同时报道，这些发现可能支持血管病变在 BCS 中起作用的观点。MRS 数据表明，在缓解后数月仍有神经元丧失和脂质代谢。血浆置换对伴有严重运动功能障碍的复发有效，且在该患者中，纳武单抗的超适应证使用在维持缓解方面是成功的。
