Centre for Statistics in Medicine, University of Oxford, UK.
BMC Med. 2012 May 29;10:51. doi: 10.1186/1741-7015-10-51.
The Reporting Recommendations for Tumor Marker Prognostic Studies (REMARK) checklist consists of 20 items to report for published tumor marker prognostic studies. It was developed to address widespread deficiencies in the reporting of such studies. In this paper we expand on the REMARK checklist to enhance its use and effectiveness through better understanding of the intent of each item and why the information is important to report.
REMARK recommends including a transparent and full description of research goals and hypotheses, subject selection, specimen and assay considerations, marker measurement methods, statistical design and analysis, and study results. Each checklist item is explained and accompanied by published examples of good reporting, and relevant empirical evidence of the quality of reporting. We give prominence to discussion of the 'REMARK profile', a suggested tabular format for summarizing key study details.
The paper provides a comprehensive overview to educate on good reporting and provide a valuable reference for the many issues to consider when designing, conducting, and analyzing tumor marker studies and prognostic studies in medicine in general. To encourage dissemination of the Reporting Recommendations for Tumor Marker Prognostic Studies (REMARK): Explanation and Elaboration, this article has also been published in PLoS Medicine.
《肿瘤标志物预后研究报告推荐规范》（REMARK）清单包含 20 项条目，用于报告已发表的肿瘤标志物预后研究。它的制定是为了解决此类研究报告中普遍存在的缺陷。在本文中，我们通过更好地理解每个条目的意图以及报告这些信息的重要性，对 REMARK 清单进行了扩展，以增强其使用和有效性。
REMARK 建议包括对研究目标和假设、受试者选择、标本和检测考虑因素、标志物测量方法、统计设计和分析以及研究结果进行透明和全面的描述。每个清单条目都进行了解释，并附有已发表的良好报告示例，以及有关报告质量的相关实证证据。我们重点讨论了“REMARK 概要”，这是一种用于总结关键研究细节的建议表格格式。
本文提供了全面的概述，旨在教育人们进行良好的报告，并为设计、进行和分析肿瘤标志物研究以及一般医学中的预后研究提供有价值的参考。为了鼓励《肿瘤标志物预后研究报告推荐规范》（REMARK）的传播：解释和阐述，本文也发表在 PLoS Medicine 上。
