Institute for Medical Biometry and Statistics, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany.
Cancer Diagnosis Program and Biometric Research Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, MD.
J Natl Cancer Inst. 2018 Aug 1;110(8):803-811. doi: 10.1093/jnci/djy088.
The Reporting Recommendations for Tumor Marker Prognostic Studies (REMARK) were developed to address widespread deficiencies in the reporting of such studies. The REMARK checklist consists of 20 items to report for published tumor marker prognostic studies. A detailed paper was published explaining the rationale behind checklist items, providing positive examples and giving empirical evidence of the quality of reporting. REMARK provides a comprehensive overview to educate on good reporting and provide a valuable reference for the many issues to consider when designing, conducting, and analyzing tumor marker studies and prognostic studies in medicine in general. Despite support for REMARK from major cancer journals, prognostic factor research studies remain poorly reported. To encourage dissemination and uptake of REMARK, we have produced this considerably abridged version of the detailed explanatory manuscript, which may also serve as a brief guide to key issues for investigators planning tumor marker prognostic studies. To summarize the current situation, more recent papers investigating the quality of reporting and related reporting guidelines are cited, but otherwise the literature is not updated. Another important impetus for this paper is that it serves as a basis for literal translations into other languages. Translations will help to bring key information to a larger audience world-wide. Many more details can be found in the original paper.
报告肿瘤标志物预后研究的推荐意见（REMARK）是为了解决此类研究报告中广泛存在的缺陷而制定的。REMARK 清单由 20 个项目组成，用于报告已发表的肿瘤标志物预后研究。详细的论文解释了清单项目背后的基本原理，提供了正面的例子，并提供了关于报告质量的经验证据。REMARK 提供了一个全面的概述，以教育良好的报告，并为设计、进行和分析肿瘤标志物研究以及一般医学中的预后研究提供了一个有价值的参考。尽管主要癌症期刊支持 REMARK，但预后因素研究报告仍然很差。为了鼓励 REMARK 的传播和采用，我们编写了这份详细解释性手稿的大幅删节版，它也可以作为计划进行肿瘤标志物预后研究的研究人员的关键问题简要指南。为了总结当前的情况，引用了更多最近调查报告质量和相关报告指南的论文，但文献没有更新。本文的另一个重要动力是，它为其他语言的直译提供了基础。翻译将有助于将关键信息带给更广泛的全球受众。更多的详细信息可以在原始论文中找到。
