1st Department of Internal Medicine & Hepato-Gastroenterology Unit, University of Ioannina School of Medicine, Ioannina, Greece.
Pancreas. 2011 May;40(4):522-32. doi: 10.1097/MPA.0b013e31820bf8ac.
The objective of this study was to assess the reporting of studies on new prognostic markers of outcome in acute pancreatitis.
We used MEDLINE searches complemented with perusal of review articles' references to identify eligible English-language studies. We included studies evaluating nonroutine markers for acute pancreatitis. Eligible outcomes included Atlanta criteria, Japanese criteria for severity, multiple/single organ failure, complications, interventional treatment, hospitalization length, and death. We generated a 47-item checklist on Acute Pancreatitis Prognosis by adapting a previously constructed reporting guidance instrument for prognostic tumor markers (REMARK [Reporting Recommendations for Tumor Marker Prognostic Studies]). The checklist addresses the reporting of essential information in prognostic studies.
The 184 identified eligible studies reported on 196 different prognostic markers. One hundred forty-four studies (78.3%) found at least 1 prognostic marker to be nominally statistically significant. Significant improvements over time were seen in the reporting for 17 items, but major deficiencies were noted even in 2004-2009 studies. Particularly, 12 items were reported in less than 10% of studies overall and even within the most recent studies.
Despite some improvements over time, the reporting of important aspects of prognostic studies in acute pancreatitis remains suboptimal. The proposed REMARK-based checklist may help improve the quality and reporting of research in this field.
本研究旨在评估急性胰腺炎新预后标志物研究的报告情况。
我们使用 MEDLINE 检索，并查阅综述文章的参考文献，以确定符合条件的英文研究。我们纳入了评估急性胰腺炎非常规标志物的研究。合格的结局包括亚特兰大标准、日本严重程度标准、多器官/单器官衰竭、并发症、介入治疗、住院时间和死亡。我们通过改编先前为肿瘤预后标志物制定的报告指南工具（REMMARK [肿瘤标志物预后研究报告建议]）生成了一个 47 项的急性胰腺炎预后检查表。该检查表涉及预后研究中基本信息的报告。
确定的 184 项合格研究报告了 196 种不同的预后标志物。144 项研究（78.3%）发现至少有 1 个预后标志物具有名义上的统计学意义。在 17 个项目的报告方面，随着时间的推移有了显著的改进，但即使在 2004-2009 年的研究中也存在重大缺陷。特别是，在总体研究中，有 12 个项目的报告比例不到 10%，甚至在最近的研究中也是如此。
尽管随着时间的推移有所改善，但急性胰腺炎预后研究中重要方面的报告仍不理想。基于 REMARK 的检查表可有助于提高该领域研究的质量和报告。
