Centro de Investigación i + 12, Hospital 12 de Octubre, Av, De Córdoba s/n, 28040, Madrid, Spain.
Proteome Sci. 2012 May 29;10(1):35. doi: 10.1186/1477-5956-10-35.
Since the advent of the new proteomics era more than a decade ago, large-scale studies of protein profiling have been used to identify distinctive molecular signatures in a wide array of biological systems, spanning areas of basic biological research, clinical diagnostics, and biomarker discovery directed toward therapeutic applications. Recent advances in protein separation and identification techniques have significantly improved proteomic approaches, leading to enhancement of the depth and breadth of proteome coverage.Proteomic signatures, specific for multiple diseases, including cancer and pre-invasive lesions, are emerging. This article combines, in a simple manner, relevant proteomic and OMICS clues used in the discovery and development of diagnostic and prognostic biomarkers that are applicable to all clinical fields, thus helping to improve applications of clinical proteomic strategies for translational medicine research.
自十多年前新蛋白质组学时代的到来以来，蛋白质谱的大规模研究已被用于鉴定广泛的生物学系统中的独特分子特征，涵盖基础生物学研究、临床诊断和针对治疗应用的生物标志物发现等领域。蛋白质分离和鉴定技术的最新进展显著改进了蛋白质组学方法，从而提高了蛋白质组覆盖的深度和广度。针对多种疾病（包括癌症和癌前病变）的蛋白质组学特征正在出现。本文以简单的方式结合了在发现和开发适用于所有临床领域的诊断和预后生物标志物中使用的相关蛋白质组学和组学线索，从而有助于改善临床蛋白质组学策略在转化医学研究中的应用。
