Université de Toulouse, UPS, IPBS, F-31077 Toulouse, France.
Cancer Lett. 2012 Nov 28;324(2):142-51. doi: 10.1016/j.canlet.2012.05.019. Epub 2012 May 27.
Among the many different cell types surrounding breast cancer cells, the most abundant are those that compose mammary adipose tissue, mainly mature adipocytes and progenitors. New accumulating recent evidences bring the tumor-surrounding adipose tissue into the light as a key component of breast cancer progression. The purpose of this review is to emphasize the role that adipose tissue might play by locally affecting breast cancer cell behavior and subsequent clinical consequences arising from this dialog. Two particular clinical aspects are addressed: obesity that was identified as an independent negative prognostic factor in breast cancer and the oncological safety of autologous fat transfer used in reconstructive surgery for breast cancer patients. This is preceded by the overall description of adipose tissue composition and function with special emphasis on the specificity of adipose depots and the species differences, key experimental aspects that need to be taken in account when cancer is considered.
在围绕乳腺癌细胞的众多不同细胞类型中，最丰富的是构成乳腺脂肪组织的细胞，主要是成熟的脂肪细胞和祖细胞。最近新积累的证据将肿瘤周围的脂肪组织作为乳腺癌进展的关键组成部分呈现出来。本综述的目的是强调脂肪组织可能通过局部影响乳腺癌细胞行为以及由此产生的临床后果来发挥作用。本文讨论了两个特别的临床方面：肥胖已被确定为乳腺癌的一个独立的预后不良因素，以及用于乳腺癌患者重建手术的自体脂肪移植的肿瘤学安全性。这之前是对脂肪组织组成和功能的全面描述，特别强调了脂肪组织的特异性和种间差异，这是在考虑癌症时需要考虑的关键实验方面。
