Lv Yuanhao, Chen Caizheng, Han Miaomiao, Tian Chenfei, Song Fuyang, Feng Sijia, Xu Miaoming, Zhao Ziyin, Zhou Hongyan, Su Wei, Zhong Jiateng
Department of Pathology, Xinxiang Medical University, Xinxiang, China.
Department of Pathology, The First Affiliated Hospital of Xinxiang Medical University, Xinxiang, China.
Cancer Cell Int. 2025 Apr 7;25(1):133. doi: 10.1186/s12935-025-03765-3.
CXCL2 (C-X-C Motif Chemokine Ligand 2), a constituent of the C-X-C chemokine subfamily, serves as a powerful chemotactic factor for neutrophils, facilitating leukocyte recruitment and movement while initiating an inflammatory response. Recent investigations have demonstrated the pivotal involvement of CXCL2 in carcinogenesis. Within the tumor microenvironment, CXCL2 modulates cellular activity primarily via its interaction with the CXCR2 receptor. The activation of signaling pathways, including ERK/MAPK, NF-κB/MAPK, PI3K/AKT, and JAK/STAT3, highlights CXCL2's inclination to promote tumorigenesis. Furthermore, the role of CXCL2 encompasses inflammatory conditions like lung inflammation, atherosclerosis, and obesity. This article examines the structural characteristics, biological roles, and molecular foundation of CXCL2 in carcinogenesis and inflammatory disorders.
CXCL2（C-X-C基序趋化因子配体2）是C-X-C趋化因子亚家族的一个组成部分，作为一种强大的中性粒细胞趋化因子，在引发炎症反应的同时促进白细胞募集和移动。最近的研究表明CXCL2在癌症发生过程中起关键作用。在肿瘤微环境中，CXCL2主要通过与CXCR2受体相互作用来调节细胞活性。包括ERK/MAPK、NF-κB/MAPK、PI3K/AKT和JAK/STAT3在内的信号通路的激活，凸显了CXCL2促进肿瘤发生的倾向。此外，CXCL2的作用还包括诸如肺部炎症、动脉粥样硬化和肥胖等炎症性疾病。本文探讨了CXCL2在癌症发生和炎症性疾病中的结构特征、生物学作用及分子基础。
