Orchard J, Young N T, Smith C, Thomas S, Darke C
Blood Bank, Cardiff Royal Infirmary, UK.
Vox Sang. 1990;59(3):172-5. doi: 10.1111/j.1423-0410.1990.tb00853.x.
A group B recipient of a group 0 kidney developed severe intravascular haemolysis due to the formation of anti-B. Immunoglobulin allotyping of donor serum, recipient serum and 'unexpected' anti-B antibody showed the antibody to be of donor origin. The patient and donor genotypes were Gm 3;5/3;5 and Gm 1,2;21/1;21, respectively, and the anti-B antibody allotype was Gm 1;21. The group B recipient of the other donor kidney showed no evidence of haemolysis. Possible factors influencing the occurrence and severity of post-transplantation haemolysis are discussed. The production of anti-A or anti-B antibodies in non-group 0 patients who receive group 0 organ transplants is well described [1-8]. We report a case of severe intravascular haemolysis in a group B patient who received a group 0 kidney, together with immunoglobulin allotyping studies which show conclusively that the antibody responsible for the haemolysis was of donor origin.
一名B组受者接受了0组肾脏移植，因产生抗B抗体而发生严重的血管内溶血。对供体血清、受者血清和“意外”抗B抗体进行免疫球蛋白同种异型分型显示，该抗体源自供体。患者和供体的基因型分别为Gm 3;5/3;5和Gm 1,2;21/1;21，抗B抗体的同种异型为Gm 1;21。另一名接受供体肾脏移植的B组受者未出现溶血迹象。文中讨论了影响移植后溶血发生和严重程度的可能因素。非0组患者接受0组器官移植时产生抗A或抗B抗体的情况已有详细描述[1-8]。我们报告了一例B组患者接受0组肾脏移植后发生严重血管内溶血的病例，同时进行的免疫球蛋白同种异型分型研究确凿表明，导致溶血的抗体源自供体。
