Hein G, Knopf B, Barta U, Müller A, Wessel G
Klinik für Innere Medizin des Bereiches Medizin, Friedrich-Schiller-Universität Jena.
Z Hautkr. 1990 Sep;65(9):824-6.
In the morning urine of 24 patients with psoriasis and that of 24 patients with psoriatic arthritis, we determined the excretion of hydroxyproline (mg HP/mumol crea), after preceding diet low in collagen. Surprisingly, psoriatic patients without articular involvement showed a significantly higher excretion of HP than those with psoriatic arthritis. Further differentiation revealed that there were no clear-cut correlations between the amount of HP excretion and the activity of the articular process; we proved, however, that the amount of HP excretion was definitely related to the activity of the skin eruptions in both groups of patients. We discuss whether an osteopathy pathogenetically associated with the skin disease (irrespective of synovitis in psoriatic arthritis) may possibly be responsible for these results.
在24例银屑病患者和24例银屑病关节炎患者的晨尿中，我们在给予低胶原蛋白饮食后测定了羟脯氨酸的排泄量（毫克羟脯氨酸/微摩尔肌酐）。令人惊讶的是，无关节受累的银屑病患者的羟脯氨酸排泄量显著高于银屑病关节炎患者。进一步分析发现，羟脯氨酸排泄量与关节病变活动度之间没有明确的相关性；然而，我们证实，两组患者中羟脯氨酸排泄量肯定与皮疹活动度相关。我们讨论了一种与皮肤病发病机制相关的骨病（无论银屑病关节炎中的滑膜炎情况如何）是否可能是这些结果的原因。
