Miyata H, Hironaka N, Ando K
Preclinical Research Laboratories, Central Institute for Experimental Animals, Kawasaki, Japan.
Yakubutsu Seishin Kodo. 1990 Sep;10(3):343-9.
The effects of subcutaneously administered scopolamine and diazepam on simultaneous as well as delayed light-dark discrimination behavior were studied in a Y-maze situation using rats. In simultaneous discrimination behavior, running responses to the lighted side of either the right or left arm of the Y-maze were regarded as correct choices. In delayed discrimination behavior, running responses to the lighted side at several delay times (0. 2, 4, and 8 sec) after extinguishment of the light were regarded as correct choices. In the saline test, the percentage of correct choices decreased as the delay time was extended. Scopolamine at 0.03 mg/kg decreased the percentage of correct choices as the delay time was extended within the range of 0 sec through 4 sec. Diazepam both at 1 mg/kg and at 2 mg/kg decreased the percentage at the delay times of 0, 2, and 4 sec but this decreasing effect was not dependent on the delay time. The same doses of these drugs had no effect on simultaneous discrimination behavior. These results suggest that scopolamine at 0.03 mg/kg and diazepam both at 1 mg/kg and at 2 mg/kg disrupt delayed discrimination behavior in different ways.
在Y型迷宫实验中，使用大鼠研究了皮下注射东莨菪碱和地西泮对同时性以及延迟性明暗辨别行为的影响。在同时性辨别行为中，大鼠跑向Y型迷宫右臂或左臂亮侧的反应被视为正确选择。在延迟性辨别行为中，灯光熄灭后在几个延迟时间（0、2、4和8秒）跑向亮侧的反应被视为正确选择。在生理盐水测试中，随着延迟时间延长，正确选择的百分比降低。0.03mg/kg的东莨菪碱在0秒至4秒的范围内随着延迟时间延长降低了正确选择的百分比。1mg/kg和2mg/kg的地西泮在延迟时间为0、2和4秒时降低了正确选择的百分比，但这种降低效应不依赖于延迟时间。相同剂量的这些药物对同时性辨别行为没有影响。这些结果表明，0.03mg/kg的东莨菪碱以及1mg/kg和2mg/kg的地西泮以不同方式干扰延迟性辨别行为。
